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The Jack-in-the-Net Architecture (Ja-Net) is a biologically-inspired approach to design adaptive n e t work applications in large-scale networks. In Ja-Net, a network application is dynamically created from a collection of autonomous components called cyber-entities. Cyber-entities rst establish relationships with other cyber-entities and collectively(More)
This paper introduces a shape-based similarity measure, called the angular metric for shape similarity (AMSS), for time series data. Unlike most similarity or dissimilarity measures, AMSS is based not on individual data points of a time series but on vectors equivalently representing it. AMSS treats a time series as a vector sequence to focus on the shape(More)
  • Robert P. Fordham, Shiro Yui, Nicholas R.F. Hannan, Christoffer Soendergaard, Alison Madgwick, Pawel J. Schweiger +6 others
  • 2013
Regeneration and homeostasis in the adult intestinal epithelium is driven by proliferative resident stem cells, whose functional properties during organismal development are largely unknown. Here, we show that human and mouse fetal intestine contains proliferative, immature progenitors, which can be expanded in vitro as Fetal Enterospheres (FEnS). A highly(More)
Although transmission of the gene expression program from mother to daughter cells has been suggested to be mediated by gene bookmarking, the precise mechanism by which bookmarking mediates post-mitotic transcriptional re-activation has been unclear. Here, we used a real-time gene expression system to quantitatively demonstrate that transcriptional(More)
In this paper, we describe the Jack-in-the-Net (Ja-Net) architecture for adaptive services in a large scale, open network environment. Using biologically inspired concepts, Ja-Net achieves built-in capabilities to create/emerge services adaptively according to dynamically changing network conditions and user preferences. In Ja-Net, a service is implemented(More)
The bilateral symmetry of the mouse embryo is broken by leftward fluid flow in the node. However, it is unclear how this directional flow is then translated into the robust, left side-specific Nodal gene expression that determines and coordinates left-right situs throughout the embryo. While manipulating Nodal and Lefty gene expression, we have observed(More)
The left-right (LR) asymmetry of visceral organs is fundamental to their function and position within the body. Over the past decade or so, the molecular mechanisms underlying the establishment of such LR asymmetry have been revealed in many vertebrate and invertebrate model organisms. These studies have identified a gene network that contributes to this(More)
Noncoding RNAs play important roles in various aspects of gene regulation. We have identified 7SK RNA to be enriched in nuclear speckles or interchromatin granule clusters (IGCs), a subnuclear domain enriched in pre-mRNA processing factors. 7SK RNA, in association with HEXIM 1 and 2, is involved in the inhibition of transcriptional elongation by RNA(More)
The determination of left-right body asymmetry in mouse embryos depends on the interplay of molecules in a highly sensitive structure, the node. Here, we show that the localization of Cerl2 protein does not correlate to its mRNA expression pattern, from 3-somite stage onwards. Instead, Cerl2 protein displays a nodal flow-dependent dynamic behavior that(More)