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  • Margaret Chiosi, Steve Wright, Don Clarke, Peter Willis Cablelabs, Chris Donley, Lane Johnson Centurylink +49 others
  • 2013
OBJECTIVES The key objective for this white paper is to provide an update on progress since we published the first joint-operator white paper on Network Functions Virtualisation in October 2012 and initiated the Network Functions Industry Specification Group (NFV ISG) under the auspices of the European Telecommunications Standards Institute (ETSI). [1] This(More)
The bilateral symmetry of the mouse embryo is broken by leftward fluid flow in the node. However, it is unclear how this directional flow is then translated into the robust, left side-specific Nodal gene expression that determines and coordinates left-right situs throughout the embryo. While manipulating Nodal and Lefty gene expression, we have observed(More)
Regeneration and homeostasis in the adult intestinal epithelium is driven by proliferative resident stem cells, whose functional properties during organismal development are largely unknown. Here, we show that human and mouse fetal intestine contains proliferative, immature progenitors, which can be expanded in vitro as Fetal Enterospheres (FEnS). A highly(More)
The left-right (LR) asymmetry of visceral organs is fundamental to their function and position within the body. Over the past decade or so, the molecular mechanisms underlying the establishment of such LR asymmetry have been revealed in many vertebrate and invertebrate model organisms. These studies have identified a gene network that contributes to this(More)
In this paper, we describe the Jack-in-the-Net (Ja-Net) architecture for adaptive services in a large scale, open network environment. Using biologically inspired concepts, Ja-Net achieves built-in capabilities to create/emerge services adaptively according to dynamically changing network conditions and user preferences. In Ja-Net, a service is implemented(More)
The Jack-in-the-Net Architecture (Ja-Net) is a biologically-inspired approach to design adaptive n e t work applications in large-scale networks. In Ja-Net, a network application is dynamically created from a collection of autonomous components called cyber-entities. Cyber-entities rst establish relationships with other cyber-entities and collectively(More)
This paper introduces a shape-based similarity measure, called the angular metric for shape similarity (AMSS), for time series data. Unlike most similarity or dissimilarity measures, AMSS is based not on individual data points of a time series but on vectors equivalently representing it. AMSS treats a time series as a vector sequence to focus on the shape(More)
To connect human biology to fish biomedical models, we sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD). The slowly evolving gar genome has conserved in content and size many entire chromosomes from bony vertebrate ancestors. Gar bridges teleosts to tetrapods by(More)
BACKGROUND Intraepithelial lymphocytes (IELs) in the intestine play important roles in the regulation of local immune responses. Although their functions have been studied in a variety of animal experiments, in vitro studies on spatiotemporal behaviors of IELs and their interaction with intestinal epithelial cells (IECs) have been hampered due to the lack(More)
Although transmission of the gene expression program from mother to daughter cells has been suggested to be mediated by gene bookmarking, the precise mechanism by which bookmarking mediates post-mitotic transcriptional re-activation has been unclear. Here, we used a real-time gene expression system to quantitatively demonstrate that transcriptional(More)