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Heteropentameric cholera toxin B subunit chimeric molecules genetically fused to a vaccine antigen induce systemic and mucosal immune responses: a potential new strategy to target recombinant vaccine…

• Tetsuya Harakuni, Hideki Sugawa, Ai Komesu, Masayuki Tadano, Takeshi Arakawa
• Infection and immunity
• 2005

Noninvasive mucosal vaccines are attractive alternatives to parenteral vaccines. Although the conjugation of vaccine antigens with the B subunit of cholera toxin (CTB) is one of the most promising… (More)

Symptomatic arachnoid cyst of the left frontal convexity presenting with memory disturbance--case report.

• Hiroki Tsurushima, Tetsuya Harakuni, A.. Saito, Daisuke Tominaga, Akihiko Hyodo, Yoshihiko Yoshii
• Neurologia medico-chirurgica
• 2000

A 48-year-old female presented with vertiginous feeling and behavior disturbance. Computed tomography showed an arachnoid cyst on the left cerebral convexity. Single photon emission computed… (More)

Plasmodium vivax ookinete surface protein Pvs25 linked to cholera toxin B subunit induces potent transmission-blocking immunity by intranasal as well as subcutaneous immunization.

• Takeshi Miyata, Tetsuya Harakuni, +6 authors Takeshi Arakawa
• Infection and immunity
• 2010

The nontoxic cholera toxin B subunit (CTB) was evaluated as a potential delivery molecule for the Plasmodium vivax ookinete surface protein, Pvs25. Recombinant Pvs25 was expressed as a secreted… (More)

Merozoite surface protein-1 of Plasmodium yoelii fused via an oligosaccharide moiety of cholera toxin B subunit glycoprotein expressed in yeast induced protective immunity against lethal malaria…

• Takeshi Miyata, Tetsuya Harakuni, Toki Taira, Goro Matsuzaki, Takeshi Arakawa
• Vaccine
• 2012

Methylotrophic yeast (Pichia pastoris) secreted cholera toxin B subunit (CTB) predominantly as a biologically active pentamer (PpCTB) with identical ganglioside binding affinity profiles to that of… (More)

Expression and secretion of cholera toxin B subunit in lactobacilli.

• Takahiro Okuno, Nobuhiro Kashige, +13 authors Fumio Miake
• Biological & pharmaceutical bulletin
• 2013

Lactic acid bacteria (LAB) are used in various fields, including in food and medical supplies. There has been a great deal of research into vaccine development using LAB as carriers due to their… (More)

[Transarterial platinum coil embolization for direct carotid-cavernous fistula].

• J Momoji, Jiro Mukawa, +4 authors Keitaro Horikawa
• No to shinkei = Brain and nerve
• 1997

Two cases of direct carotid-cavernous fistula (CCF) were treated by transarterial platinum coil embolization (TACE) following unsuccessful transarterial balloon embolization (TABE). Case 1 was a… (More)

Cholera toxin B subunit-five-stranded α-helical coiled-coil fusion protein: "five-to-five" molecular chimera displays robust physicochemical stability.

• Takeshi Arakawa, Tetsuya Harakuni
• Vaccine
• 2014

To create a physicochemically stable cholera toxin (CT) B subunit (CTB), it was fused to the five-stranded α-helical coiled-coil domain of cartilage oligomeric matrix protein (COMP). The chimeric… (More)

Stenting for atherosclerotic stenosis of the intracranial or skull base cerebral arteries. Effectiveness and problems.

• Tetsuya Harakuni, Akihiko Hyodo, +6 authors Yuji Matsumaru
• Interventional neuroradiology : journal of…
• 2004

SUMMARY Since May 1992, we have performed percutaneous transluminal angioplasty (PTA) or stenting 70 times for 65 lesions in 62 patients with atherosclerotic stenosis of the intracranial or skull… (More)

Enhanced effect of BCG vaccine against pulmonary Mycobacterium tuberculosis infection in mice with lung Th17 response to mycobacterial heparin-binding hemagglutinin adhesin antigen.

• Masayuki Fukui, Kikuko Shinjo, +4 authors Goro Matsuzaki
• Microbiology and immunology
• 2015

Although the BCG vaccine can prevent tuberculosis (TB) in infants, its ability to prevent adult pulmonary TB is reportedly limited. Therefore, development of a novel effective vaccine against… (More)

Japanese encephalitis virus structural and nonstructural proteins expressed in Escherichia coli induce protective immunity in mice.

• Senji Tafuku, Takeshi Miyata, +5 authors Takeshi Arakawa
• Microbes and infection
• 2012

Ectodomain of Japanese encephalitis virus (JEV) E protein [domains I through III (D1-3), domains I and II (D1-2) and domain III (D3)] and the nonstructural protein 1 (NS1) were expressed in… (More)

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