Tetsushi Fujisaki

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We investigated the antinociceptive effects produced by peripheral electric stimulation (PES) in mice and the influence of administration of L-5-hydroxytryptophan (5-HTP), methysergide and naloxone on the antinociceptive effect of the PES. Administration of 5-HTP enhanced antinociceptive effects induced by PES, while methysergide and naloxone abolished this(More)
Establishment of electromagnetic compatibility is important in use of electronic medical equipment in hospitals. To evaluate the electromagnetic environment, the electric field intensity induced by electromagnetic radiation in broadcasting spectra coming from outside the hospital was measured in a new hospital building before any patients visited the(More)
Brain ischemia causes irreversible hyperexcitability, which may be attributed to irreversible impairment of inhibitory neurons. However, the conditions required for selective and irreversible impairment of inhibitory interneurons in vitro are unknown. In this study, we found that a combination of low temperature and hypoxia produced hyperexcitability in the(More)
To elucidate the mechanisms of neural damage after brain ischemia, rat neocortical slices were exposed to anoxia at room temperature for 1 h, and other slices were prepared from the neocortical blocks exposed to anoxia at room temperature for 1 h. Field potentials elicited by the stimulation of layer IV were recorded in supragranular layers in these slices.(More)
To maintain neural functions in brain block preparations of the rat auditory cortex in vitro, a pressurized oxygenated medium was injected into the blocks. Distribution of indigo carmine contained in the injection medium indicated that a columnar region of 1-2 mm in diameter was homogeneously perfused from the white matter to the pial surface. Stimulation(More)
Methylmercury chloride was administered PO to male Kud: ddY mice at a dose of 5 mg/kg/day for 20 days. The contents of taurine, aspartate, glutamate, glycine, and gamma-aminobutyric acid were determined in tissue and crude synaptosomal (P2) fraction of cerebellum, cerebral cortex, and spinal cord of methylmercury-treated mice with or without ataxia. In the(More)
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