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Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant.
- Yasushi Ichimura, T. Habuchi, +6 authors Tetsuro Kato
- Biology, Medicine
- The Journal of urology
- 1 August 2004
The GPX1 Pro/Leu genotype may significantly increase the risk of bladder cancer and the increased risk may be modified by the Ala-9Val MnSOD polymorphism. Expand
Cyclin D1 gene polymorphism is associated with an increased risk of urinary bladder cancer.
The data suggest that the CCND1 variant A allele may be associated with an increased risk of TCC of the bladder, especially in men without a history of smoking, and it may also have an effect on its disease status. Expand
Increased risk of prostate cancer associated with AA genotype of cyclin D1 gene A870G polymorphism
- Lizhong Wang, T. Habuchi, +9 authors Tetsuro Kato
- Biology, Medicine
- International journal of cancer
Although the risk of PCa associated with the AA genotype appeared to contribute especially to men aged 73 years or younger and the A allele may be associated with disease status ofPCa, these conjectures require validation in future studies on a larger number of subjects. Expand
Influence of CYP3A5 and MDR1 (ABCB1) Polymorphisms on the Pharmacokinetics of Tacrolimus in Renal Transplant Recipients
Kidney transplant recipients with the CYP3A5 *1 allele required a higher daily tacrolimus dose compared with those with the cytochrome P450 3A5*3/*3 genotype to maintain both the target trough level and AUC0–12, suggesting that this polymorphism is useful for determining the appropriate dose of tacolimus. Expand
Association of V89L SRD5A2 polymorphism with prostate cancer development in a Japanese population.
The V allele of the V89L polymorphism in the SRD5A2 gene may dominantly increase the risk of prostate cancer. Expand
Increased risk of prostate cancer and benign prostatic hyperplasia associated with transforming growth factor-beta 1 gene polymorphism at codon10.
The results suggest that the codon10 polymorphism in TGFB1 may have a significant influence on the development of PCa and BPH, therefore underscoring the importance of the TGF pathway in theDevelopment of these prostatic diseases. Expand
Increased Serum Levels of Vascular Endothelial Growth Factor in Patients with Renal Cell Carcinoma
- Kazunari Sato, N. Tsuchiya, +4 authors Tetsuro Kato
- Japanese journal of cancer research : Gann
- 1 August 1999
The results indicate that tumor tissue of RCC liberates VEGF into the systemic blood flow and that s‐VEGF is a possible marker for RCC. Expand
Polymorphisms in prostate-specific antigen (PSA) gene, risk of prostate cancer, and serum PSA levels in Japanese population.
The PSA polymorphisms may not be associated with therisk of prostate cancer development and its disease progression and the risk of BPH in Japanese men, and may also be not related to the serum PSA level inJapanese men with prostate cancer. Expand
Early and large‐dose intravesical instillation of epirubicin to prevent superficial bladder carcinoma recurrence after transurethral resection
To prospectively compare the prevention of tumour recurrence by four intravesical adjuvant administration protocols, and thus elucidate the efficacy of early and high total dose instillations of… Expand
Prospective evaluation of selection criteria for active surveillance in Japanese patients with stage T1cN0M0 prostate cancer.
- Y. Kakehi, T. Kamoto, +25 authors M. Niwakawa
- Japanese journal of clinical oncology
- 1 February 2008
The primary endpoint, '%PSADT > 2y', did not meet the pre-specified decision criteria and further prospective study with revised program and endpoint is needed. Expand