Tetsuro Isada

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As TrkA, a high-affinity receptor of nerve growth factor (NGF), is a potential target for relieving uncontrolled inflammatory pain, an effective inhibitor of TrkA has been required for pain management. To identify a specific inhibitor of TrkA activity, we designed cell-penetrating peptides combined with amino-acid sequences in the activation loop of TrkA to(More)
Hyperbaric exposure induces lesions of the CNS in scuba divers. Repeated exposures to hyperbaric air at 0.5 MPa for 30 min with short intervals suppressed NGF-stimulated neurite outgrowth, concomitant with a decrease in the protein expression of ERK in PC12 cells. Hyperbaric exposure most likely causes direct lesions of neural cells.
BACKGROUND We are faced sometimes with the difficult pediatric airway due to congenital abnormalities. However, there has been no systematic examination for the management of the difficult pediatric airway. METHODS We retrospectively examined the incidence of difficult airway in 13,557 pediatric patients who had undergone general anesthesia with tracheal(More)
Mediastinal rightward shift without involving cardiovascular collapse and dyspnea occurred after a left nephroureterectomy. An 86-year-old female (height, 142 cm; weight, 53 kg) with ureteral cancer was scheduled for an elective nephroureterectomy. Preanesthetic electrocardiogram revealed supraventricular premature contractions and sinus tachycardia (116(More)
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