Tetsuro Hamaoka

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21 Muscle-restricted coiled-coil protein (MURC), also referred to as Cavin-4, is a member of 22 the cavin family that works cooperatively with caveolins in caveola formation and function. 23 Cavins are cytoplasmic proteins with coiled-coil domains and form heteromeric 24 complexes, which are recruited to caveolae in cells expressing caveolins. Among 25(More)
Emerging evidence suggests that caveolin-1 (Cav1) is associated with pulmonary arterial hypertension. MURC (also called Cavin-4) is a member of the cavin family, which regulates caveolar formation and functions together with caveolins. Here, we show that hypoxia increased Murc mRNA expression in the mouse lung, and that Murc-null mice exhibited attenuation(More)
Mutations in the PTRF/Cavin-1 gene cause congenital generalized lipodystrophy type 4 (CGL4) associated with myopathy. Additionally, long-QT syndrome and fatal cardiac arrhythmia are observed in patients with CGL4 who have homozygous PTRF/Cavin-1 mutations. PTRF/Cavin-1 deficiency shows reductions of caveolae and caveolin-3 (Cav3) protein expression in(More)
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