Tetsuo Nagasaka

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The effect of running on heat production in brown adipose tissue (BAT) was compared between trained and untrained rats. Rats were forced to run a treadmill while temperatures of colon (T col) and interscapular BAT (T bat) were measured. The daily running for 5 weeks neither changed the size of interscapular BAT nor the norepinephrine-induced thermogenesis(More)
We describe a 42-year-old man with von Hippel-Lindau disease and islet cell tumor of the pancreas. He had retinal and cerebellar hemangioblastomas. His sister had pheochromocytoma. A pancreatic tumor was detected by ultrasonography at his periodical medical checkup. Contrast enhanced computed tomography and abdominal angiography revealed a hypervascular(More)
Local concentrations of the vasopressor peptide, angiotensin II (AngII), depend upon the balance between synthesis and degradation. Previous studies of blood pressure (BP) regulation have focused primarily on the generation of AngII and its receptors, and less attention has been devoted to angiotensin degradation. Aminopeptidase A (APA, EC is(More)
The role of the ventromedial hypothalamic nucleus (VMH) in the generation of the prefeeding corticosterone peak was examined in rats under restricted daily feeding, under which daily meal supply was restricted to a fixed time in the early light period. Rats were lesioned in the VMH bilaterally and subjected to restricted daily feeding during two different(More)
The mechanisms of the hypothermic effect of angiotensin II (AII) injected into the lateral ventricle were investigated in unanesthetized rats at an ambient temperature of 18 degrees C. Mean blood pressure (BP), heart rate (HR), metabolic rate (M), colonic temperature (Tcol), and temperatures of the interscapular brown adipose tissue (TBAT), and the tail(More)
This study investigated the day-night differences in behavioral and autonomic thermoregulatory responses to bacterial lipopolysaccharide (LPS) in rats. Male rats were housed individually in cages with a 12: 12 h light dark cycle at an ambient temperature of 24 degrees C. The rats were placed in a box with a temperature gradient and intraperitoneally(More)
1. Heat-acclimated (HA) rats, kept under a 12:12 h light-dark regime, were subjected to an ambient temperature (Ta) of 33 degrees C for 5 h in the last half of the dark phase for 3 weeks. Control rats were kept under a 12:12 h light-dark regime at a constant Ta of 24 degrees C. 2. After the acclimation period, the rats were then placed in a metabolic(More)
The effect of a single cortical spreading depression (CSD), elicited unilaterally by 10% KCI injection at the occipital cortex, was observed on the metabolic heat production in the rat with unilateral lesions in the preoptic and anterior hypothalamus (PO/AH). The metabolic rate increased by maximally 20% above its pre-CSD level for 7 min with a rise in(More)
The effects of intracerebroventricular (icv) vasoactive intestinal polypeptide (VIP), secretin, glucagon, and cholecystokinin-octapeptide (CCK-8) on the thermoregulatory and cardiovascular systems were studied in conscious rats. The icv injection of VIP at a dose of 10 micrograms produced hyperthermia with an increase in the positive difference between the(More)
Male Wistar rats were divided into two groups. The controls (CN) were kept at a constant ambient temperature (Ta) of 24 degrees C throughout the experiment. Heat-acclimated rats (HA) were subjected to Ta of 33 degrees C in the last half of the dark phase for 16 consecutive days. After the schedule was terminated, hypothalamic temperature (Thy), oxygen(More)