Tetsuaki Matsumoto

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We designed a simple, rapid, and continuous method for the detection of the activity of histone deacetylases (HDACs), which are key enzymes involved in epigenetic gene regulation, using a DNA-based fluorogenic probe. We designed and synthesized a fluorogenic probe, BOXTO-GK(Ac)G, which is a DNA staining dye-peptide conjugate containing an acetylated lysine.(More)
Physically and chemically stable microscopic aqueous droplets of nano-, pico-, and femtoliter volumes were made and kept under heptane. Such droplets can contain chemicals of interest in pico-, femto-, and attomole amounts or less. Their fine chemical manipulation was achieved by a diffusional microburet (DMB), which consists of a pulled glass capillary(More)
Microscopic liquid particles can be manipulated chemically using a suitable diffusional microburet (DMB), whose tiny tip plugged with a diffusion membrane acts as a well-defined diffusional transfer channel. In part 1 of this work (Gratzl et al. Anal. Chem. 1999, 71, 2751-2756), we discussed the simplest DMB-based operation: addition, i.e., loading a(More)
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