Tetsuaki Makino

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In DNA, 8-oxo-7,8-dihydroguanine (GO, 8-hydroxyguanine) is one of the most pivotal oxidatively damaged bases and induces G:C → T:A transversion mutations. DNA polymerase λ preferentially inserts dCTP opposite GO in vitro, and this error-free bypass function is considered to be important after A base removal from GO:A pairs by the MUTYH DNA glycosylase. To(More)
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