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  • Serena Marchetti, Nienke A de Vries, +6 authors Jan H M Schellens
  • Biology, Medicine
  • Molecular cancer therapeutics
  • 2008 (First Publication: 1 August 2008)
  • UNLABELLED We tested whether erlotinib hydrochloride (Tarceva, OSI-774), an orally active epidermal growth factor receptor tyrosine kinase inhibitor, is a substrate for the ATP-binding cassette drugContinue Reading
  • Jacobus Burggraaf, Ingrid Maria Catharina Kamerling, +20 authors James C. H. Hardwick
  • Medicine
  • Nature Medicine
  • 2015 (First Publication: 13 July 2015)
  • Colon cancer prevention currently relies on colonoscopy using white light to detect and remove polyps, but small and flat polyps are difficult to detect and frequently missed when using thisContinue Reading
  • Nienke A de Vries, Jin Zhao, Emily Kroon, Tessa Buckle, Jos H. Beijnen, Olaf van Tellingen
  • Biology, Medicine
  • Clinical cancer research : an official journal of…
  • 2007 (First Publication: 1 November 2007)
  • PURPOSE The brain is a pharmacologic sanctuary site, due to the presence of the blood-brain barrier (BBB). Whereas the effect of P-glycoprotein (P-gp) at the BBB is well established, the role ofContinue Reading
  • Roos L. Oostendorp, Tessa Buckle, Jos H. Beijnen, Olaf van Tellingen, Jan H M Schellens
  • Chemistry, Medicine
  • Investigational New Drugs
  • 2008 (First Publication: 1 February 2009)
  • SummaryImatinib is transported by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP), however, the exact impact of these transporters on absorption, distribution, metabolism andContinue Reading
  • Nienke A. de Vries, Tessa Buckle, Jin Zhao, Jos H. Beijnen, Jan H M Schellens, Olaf van Tellingen
  • Medicine
  • Investigational New Drugs
  • 2010 (First Publication: 1 April 2012)
  • SummaryPurpose Erlotinib (Tarceva®, OSI-774) is a small molecule inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. As high-grade gliomas frequently show amplification,Continue Reading
  • Henk G van der Poel, Tessa Buckle, Oscar R Brouwer, Renato A. Valdés Olmos, Fijs W. B. van Leeuwen
  • Medicine
  • European urology
  • 2011 (First Publication: 1 October 2011)
  • BACKGROUND Integration of molecular imaging and in particular intraoperative image guidance is expected to improve the surgical accuracy of laparoscopic lymph node (LN) dissection. OBJECTIVE ToContinue Reading
  • Oscar R Brouwer, Tessa Buckle, +8 authors Renato A. Valdés Olmos
  • Medicine
  • Journal of nuclear medicine : official…
  • 2012 (First Publication: 1 July 2012)
  • UNLABELLED The purpose of this study was to compare the lymphoscintigraphic drainage patterns of a hybrid sentinel node tracer consisting of the fluorescent dye indocyanine green (ICG) andContinue Reading