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PURPOSE To study the effects of aging on corneal biomechanical properties and their impact on 24-hour measurement of intraocular pressure (IOP). DESIGN Experimental study. METHODS Fifteen older volunteers with healthy eyes (age range, 50 to 80 years) were housed for one day in a sleep laboratory with a 16-hour diurnal or wake period and an eight-hour(More)
BACKGROUND Meteorologic factors play a role in the expression of asthmatic symptoms; however, there are controversies about the causal relationship between meteorologic factors and asthma. The relationship between meteorologic parameters and emergency admissions for asthmatic symptoms in this hospital were analyzed. METHODS A total of 205 patients (130(More)
In 12,505 patients who received barium enemas during the past 14 days, 979 cases (7.8%) of diverticular disease of the colon (DDC) were found. The incidence of DDC increased with age; 2.2% of the patients were below age 29 and 14.3% were over 70 years old. The sex distribution was 584 males and 395 females. 76.1% had diverticula in the right-side colon,(More)
The purpose of this study was to report the surgical outcomes after creating a 120° intentional giant retinal tear for use in removing hemorrhage and subretinal proliferative tissue in patients with polypoidal choroidal vasculopathy (PCV) or age-related macular degeneration (ARMD). This study involved 12 eyes of 12 patients (10 eyes: PCV, 2 eyes: ARMD).(More)
PURPOSE To assess the influence of the blood glucose level on ocular capillary circulation, we induced clinically significant hyperglycemia (200--300 mg/dl) in rabbits and investigated the changes in the optic nerve head (ONH) circulation. METHODS Hyperglycemia was induced by injection of glucose (5.6 mmol/kg) into an auricular vein of healthy albino(More)
Modulation of enzyme activity through nitrosylation has recently been identified as a new physiological activity of nitric oxide (NO). We hypothesized that NO enhances the TNF-α-induced death of retinal neurons through a suppression of nuclear factor-κB (NF-κB) by nitrosylation. In this study, cells from the RGC-5 line were exposed to different(More)
Neuroinflammation is involved in the death of retinal ganglion cells (RGCs) after optic nerve injury. The purpose of this study was to determine whether systemic simvastatin can suppress neuroinflammation in the optic nerve and rescue RGCs after the optic nerve is crushed. Simvastatin or its vehicle was given through an osmotic minipump beginning one week(More)
The new term Flammer syndrome describes a phenotype characterized by the presence of primary vascular dysregulation together with a cluster of symptoms and signs that may occur in healthy people as well as people with disease. Typically, the blood vessels of the subjects with Flammer syndrome react differently to a number of stimuli, such as cold and(More)
PURPOSE The difference in preferences and trends of treatment in each country are important to plan an international interventional clinical study in eastern Asia. Accordingly, we compared the preferences and trends in treatment of diabetic retinopathy in Korea and Japan. METHODS We obtained answers to questionnaires (49 questions) from 91(More)
Pirarubicin, a new antineoplastic antibiotic of anthracycline derivative, was injected into the pleural cavity in 15 patients with malignant pleural effusion. The dose of pirarubicin was 40 mg or 80 mg/body. All 15 patients were evaluable for both efficacy and toxicity. Since one evaluable patient received two courses of intrapleural administration of(More)