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CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA
Centromere protein (CENP) B boxes, recognition sequences of CENP-B, appear at regular intervals in human centromeric α-satellite DNA (alphoid DNA). In this study, to determine whether informationExpand
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CENP-B Controls Centromere Formation Depending on the Chromatin Context
The centromere is a chromatin region that serves as the spindle attachment point and directs accurate inheritance of eukaryotic chromosomes during cell divisions. However, the mechanism by which theExpand
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Construction of a novel human artificial chromosome vector for gene delivery.
Potential problems of conventional transgenes include insertional disruption of the host genome and unpredictable, irreproducible expression of the transgene by random integration. Alternatively,Expand
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An Artificially Constructed De Novo Human Chromosome Behaves Almost Identically to Its Natural Counterpart during Metaphase and Anaphase in Living Cells
ABSTRACT Human artificial chromosomes (HACs) are promising reagents for the analysis of chromosome function. While HACs are maintained stably, the segregation mechanisms of HACs have not beenExpand
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[Human artificial chromosome].
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[Chromosome assembly controls: perspective from the observation of human artificial chromosomes].
Human Artificial Centromeres: De novo Assembly of Functional Centromeres on Human Artificial Chromosomes
The centromere is a chromosomal domain that is required for correct segregation of eukaryotic chromosomes during mitotic and meiotic cell division. CENP-A is a centromere-specific histone H3 variantExpand