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NIMH guidelines to manage subjects who are suicidal during their participation in clinical trials include a full range of procedures to minimize suicidal risk, yet no reports to date have shown how researchers should best implement these guidelines. The architects of the sequenced treatment alternatives to relieve depression (STAR*D) study operationalized(More)
BACKGROUND Anxious depression, defined as Major Depressive Disorder (MDD) with high levels of anxiety symptoms, may represent a relatively common depressive subtype, with distinctive features. OBJECTIVE The objective of this study was to determine the prevalence of anxious depression and to define its clinical correlates and symptom patterns. METHOD(More)
This article presents findings from an outpatient dual diagnosis demonstration project that investigated whether integrated treatment services for severely and persistently ill patients with co-occurring mental health and substance abuse disorders could result in improved outcomes and reduction of criminal justice and health care costs. Integrated treatment(More)
Second-generation antipsychotics (SGAs) are used for the treatment of multiple psychiatric disorders including schizophrenia, bipolar depression, bipolar mania, autism and major depressive disorder. Additionally, their off-label use has been expanding to include other disorders as well, including post-traumatic stress disorder, obsessive compulsive(More)
4 ACKNOWLEDGMENTS A special thank you goes to the Greenbook Executive and Oversight Committees (See Appendix A) for their ongoing support of the project. Without their willingness to be self-evaluative and their commitment to creating a differential response for families, our community would not have been able to implement the Institutional Safety &(More)
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