Terry L. Woodward

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Postnatal mammary gland development is highlydependent on the ovarian steroids, estrogen andprogesterone. However, evidence from both in vitro andin vivo studies indicates that steroid-induceddevelopment occurs indirectly, requiring stromalcooperation in epithelial proliferation andmorphogenesis. Stromal cells appear to influenceepithelial cell behavior by(More)
Extracellular matrix (ECM) proteins have been shown to regulate mammary epithelial cell proliferation, differentiation, and apoptosis in vitro. However, little is known about the hormonal regulation and functional role of ECM proteins and integrins during mammary gland development in vivo. We examined the temporal and spatial localization and hormone(More)
The acute temporal effects of exogenous oestradiol (0.1 mg/kg per day), progesterone (0.25 mg/kg per day) or both together on the proliferative response of epithelial cells, fibroblasts, adipocytes and endothelial cells in the mammary tissue of prepubertal cross-bred heifers were determined. Mammary biopsies were taken immediately before, then 24, 48 and 96(More)
Breast tumors that lack estrogen responsiveness have a poor prognosis. Despite the critical importance to breast cancer treatment, little is known about the loss of estrogen responsiveness and the development of antiestrogen resistance. We have examined the regulation of estrogen-induced proliferation, estrogen regulation of progesterone receptor (PR)(More)
Mammary epithelial cells comprise the functional component of the normal gland and are the major target for carcinogenesis in mammary cancer. However, the stromal compartment of the normal gland and of tumors plays an important role in directing proliferative and functional changes in the epithelium. In vivo and in vitro studies of the murine mammary gland(More)
The purpose of the present study was to investigate the role of extracellular matrix proteins (ECMs; collagens I and IV, fibronectin, and laminin) in modulating proliferative responses of normal mammary epithelial cells in serum-free culture to epidermal growth factor (EGF) and insulin-like growth factor I (IGF-I). As EGF and IGF-I can alter steroid(More)
Despite the critical importance of ovarian steroids in the treatment of breast cancer, little is known about the acquisition or loss of estrogen and progesterone responsiveness in either the normal or neoplastic mammary gland. This review focuses on the interactions among mammary stroma-derived extracellular matrix (ECM) proteins, integrins and ovarian(More)
Award Number DAMD17-96-1-6026 TITLE: Role of Stroma-Derived Extracellular Matrix in Regulation of Growth and Hormon'al Responsiveness of Normal and Cancerous Human Breast Epithelium PRINCIPAL INVESTIGATOR: Terry L. Woodward CONTRACTING ORGANIZATION: Michigan State University East Lansing, Michigan 48824-1101 REPORT DATE: September 1998 TYPE OF REPORT:(More)
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