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The Kennedy pathway—De novo synthesis of phosphatidylethanolamine and phosphatidylcholine
This review will cover various aspects of theKennedy pathway including: each of the biosynthetic steps, the functions androles of the phospholipid products PC and PE, and how the Kennedy pathway has the potential of being a chemotherapeutic target against cancer and various infectious diseases.
Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites
Chemical genetics and a global comparative analysis of phosphorylation and phospholipids in vivo shows that PKG is the upstream regulator that induces calcium signals that enables Plasmodium to…
Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei
The profile of regulated gene expression during these important life-cycle transitions of trypanosome differentiation is established using stringent statistical analysis and validation of the derived profiles against experimentally-predicted gene expression and phenotypic changes.
Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice
Phosphatidylinositol synthesis is essential in bloodstream form Trypanosoma brucei.
The results presented here show that PI synthesis is essential for bloodstream form T. brucei, and to the authors' knowledge this is the first report of the dependence on PI synthesis of a protozoan parasite by genetic validation.
Structure and reactivity of LpxD, the N-acyltransferase of lipid A biosynthesis
- L. Buetow, Terry K. Smith, A. Dawson, S. Fyffe, W. Hunter
- Chemistry, BiologyProceedings of the National Academy of Sciences
- 13 March 2007
The placement of UDP-N-acetylglucosamine and the FA provides details of N-acyltransferase ligand interactions and allows for a description of structure and reactivity at an early stage of LPS assembly.
Apicoplast Lipoic Acid Protein Ligase B Is Not Essential for Plasmodium falciparum
Evidence is provided that residual lipoylation in Plasmodium is attributable to the dual targeted, functional lipoate protein ligase 2 (LplA2), suggesting redundancy between the lipoic acid protein ligases in the erythrocytic stages of P. falciparum.
Mitochondrial fatty acid synthesis is required for normal mitochondrial morphology and function in Trypanosoma brucei
- Jennifer L. Guler, E. Kriegová, Terry K. Smith, J. Lukeš, P. T. Englund
- BiologyMolecular microbiology
- 1 March 2008
It is concluded that the mitochondrial synthase produces fatty acids needed for maintaining local phospholipid levels that are required for activity of respiratory complexes and preservation of mitochondrial morphology and function.
The glycosylphosphatidylinositol (GPI) biosynthetic pathway of bloodstream‐form Trypanosoma brucei is dependent on the de novo synthesis of inositol
Supporting these results, there was no change in PI levels in the conditional double knockout cells grown under non‐permissive conditions, showing that perturbation of growth is due to a specific lack of de novo synthesized myo‐inositol and not a general inositol‐less death.
The role of lipids in mechanosensation
- C. Pliotas, A. Dahl, J. Naismith
- Biology, ChemistryNature Structural &Molecular Biology
- 21 October 2015
It is proposed that the extent of acyl-chain interdigitation in these pockets determines the conformation of MscS, and it is shown that the volume of the pockets and thus the number of lipid acyl chains within them decreases upon channel opening.