Terry J. B. Walker

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The aim of this study is to review advances in basic and clinical allergic rhinitis (AR) research over the past decade that have been conducted using controlled allergen challenge facility (CACF) models of allergen challenge. Databases, including PubMed, Medline, and Web of Science were searched for articles employing an ambient pollen exposure in a(More)
RATIONALE The Environmental Exposure Unit (EEU), a controlled allergen exposure model of allergic rhinitis (AR), has traditionally utilized ragweed pollen. We sought to clinically validate the use of grass pollen in the EEU. METHODS Healthy volunteers with a history of AR symptoms during grass pollen season and supportive skin test responses attended the(More)
BACKGROUND Oral antihistamines that target the histamine receptor-1, such as fexofenadine, offer suboptimal relief of allergic rhinitis-associated nasal congestion. Combinations with oral sympathomimetics, such as pseudoephedrine, relieve congestion but produce side effects. Previous animal and human studies with histamine receptor-3 antagonists, such as(More)
BACKGROUND Azelastine has been shown to be effective against seasonal allergic rhinitis (SAR). The Environmental Exposure Unit (EEU) is a validated model of experimental SAR. The objective of this double-blind, four-way crossover study was to evaluate the onset of action of azelastine nasal spray, versus the oral antihistamines loratadine 10 mg and(More)
Methods Airborne grass pollen was collected in the EEU via a Rotorod impact sampler. The pollen grains on each sampling rod were counted using both traditional and headsup microscopy. The heads-up technique incorporated a microscope camera to create an on-screen image of the sampling rod. Firstly, unique images were created by manually advancing the stage,(More)
BACKGROUND The Environmental Exposure Unit (EEU) in Kingston, Ontario, Canada is a controlled allergen challenge facility (CACF) that has been previously clinically validated for the use of ragweed and grass pollen in clinical studies. In this study we aim to validate the use of birch pollen to challenge allergic participants. METHODS A total of 59(More)
Methods Advanced scanning technologies are used with a customized two-step quality assurance data collection process. Optical Mark Recognition (OMR) and Optical Character Recognition (OCR) capture data from paper symptom diary cards into the EEU’s clinical data management system (CDMS). A template is configured to read the static diary card format and(More)
Background Oral histamine receptor–1 antagonists, such as fexofenadine, offer suboptimal relief of allergic rhinitis-associated nasal congestion. Combinations with oral sympathomimetics, such as pseudoephedrine, relieve congestion but produce side effects. Histamine receptor-3 antagonists, such as PF-03654764, reduce congestion in animals and have been(More)
Retraction This meeting abstract [1], published in the Canadian Society of Allergy and Clinical Immunology and AllerGen Abstracts 2014 supplement, has been retracted from Allergy, Asthma & Clinical Immunology by the authors. The meeting abstract has previously been published in Journal of Allergy and Clinical Immunology [2] and was inadvertently submitted(More)
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