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Temporary cerebral ischemia. Effects of pentastarch or albumin on reperfusion injury.
Recent investigations have proposed that, after temporary ischemia, pentastarch may reduce microvascular permeability and reperfusion injury. However, this hypothesis has not been tested in theExpand
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Low dose L-NAME reduces infarct volume in the rat MCAO/reperfusion model.
In a variety of recent studies, inhibitors of nitric oxide (NO) synthesis have ameliorated neuronal injury during permanent focal cerebral ischemia, suggesting that NO may contribute to ischemicExpand
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L-NAME Reduces Infarct Volume in a Filament Model of Transient Middle Cerebral Artery Occlusion in the Rat Pup
ABSTRACT: The importance of nitric oxide (NO) during focal cerebral ischemia remains controversial as studies have suggested both a neurotoxic and neuroprotective role. In the 7 d old rat pup,Expand
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A new model of neonatal stroke: reversible middle cerebral artery occlusion in the rat pup.
Neonatal stroke remains a complex pathophysiologic process that is poorly understood and difficult to investigate. The primary animal model used to study this phenomenon is that of unilateral carotidExpand
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Dual effects of L-NAME during transient focal cerebral ischemia in spontaneously hypertensive rats.
The role of nitric oxide (NO) in ischemic neuronal injury is unclear. In permanent focal ischemia models, NO release has been reported to be both neuroprotective, by virtue of actions to improveExpand
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Brain eicosanoid levels during temporary focal cerebral ischemia in rats: a microdialysis study.
After transient cerebral ischemia, the brain is vulnerable to additional injury via hypoperfusion deficits. Eicosanoids with vasoconstrictor properties, such as thromboxane A2 (TxA2), may worsenExpand
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Hypertension and hemodilution during cerebral ischemia reduce brain injury and edema.
The extent of cerebral injury and edema was determined in isoflurane-anesthetized rats (n = 32) after 180 min of middle cerebral artery occlusion (MCAO) and 120 min of reperfusion. One of theExpand
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Effect of an Anion Transport Inhibitor, L‐644,711, on Brain Injury and Edema After Temporary Middle Cerebral Artery Occlusion in Rats
&NA; The affect of L-644,711, an anion transport inhibitor, on ischemic brain injury and edema was investigated. Spontaneously hypertensive rats were given one of the following doses of intrathecalExpand
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