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We report on the unexpected structural changes caused by substitution of acidic amino acids in the Q(B) binding pocket of the bacterial photosynthetic reaction center by alanines. The mutations targeted key residues L212Glu and L213Asp of this transmembrane protein-cofactor complex. The amino acid substitutions in the L212Ala-L213Ala mutant reaction center(More)
The virtual enterprise (VE), which is formed according to some business opportunities through the collaboration of supply chain partners, is an effective way of business operation in the dynamic global market. This paper proposes an automated negotiation protocol for multi-agent system (MAS) based virtual enterprises. Firstly, to facilitate the functional(More)
Therapy-related acute myeloid leukaemia (t-AML) and therapy-related myelodysplastic syndrome (t-MDS) are well-recognized complications of cytotoxic chemotherapy and/or radiotherapy. There are several features that distinguish t-AML from de novo AML, including a higher incidence of TP53 mutations, abnormalities of chromosomes 5 or 7, complex cytogenetics and(More)
RNA folding in the cell occurs during transcription. Expedient RNA folding must avoid the formation of undesirable structures as the nascent RNA emerges from the RNA polymerase. We show that efficient folding during transcription of three conserved noncoding RNAs from Escherichia coli, RNase P RNA, signal-recognition particle RNA, and tmRNA is facilitated(More)
This paper presents a new method for modeling cloth deformation. The proposed approach is a constrained finite element method. We successfully introduce a geometric constraint into the geometrical, non-linear, finite element equations. The assumed constraint is that lengths of all threads in a cloth object remain unchanged after deformation. Using the(More)
There is interest in using leukemia-gene panels and next-generation sequencing to assess acute myelogenous leukemia (AML) response to induction chemotherapy. Studies have shown that patients with AML in morphologic remission may continue to have clonal hematopoiesis with populations closely related to the founding AML clone and that this confers an(More)
# These authors contributed equally to this work. Therapy-related acute myeloid leukemia (t-AML) and therapy-related myelodysplastic syndrome (t-MDS) are well-recognized complications of cytotoxic chemotherapy and/or radiotherapy 1. There are several features that distinguish t-AML from de novo AML including a higher incidence of TP53 mutations 2,3 ,(More)