Terrence Lawson

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BACKGROUND Previously, in murine models of acid maltase deficiency (AMD), we demonstrated that intravenous administration of an improved adenovirus (Ad) vector encoding human acid alpha glucosidase (hGAA) resulted in liver transduction, followed by high-level hepatocyte-mediated secretion of hGAA into the plasma space. The hGAA secreted by the liver was(More)
In spite of increasing interest in the use of haemodialysis, there have been few reports of its use in infancy and childhood (Mateer, Greenman and Danowski, 1955; Carter, Aoyama, Mercer and Kolff, 1957; Keleman and Kolff, 1959; Breakey, Woodruff and Reus, 1961). We present here our experience of this problem in three children who were suffering from acute(More)
Studies in animals have demonstrated that glutathione levels and the activities of glutathione S-transferase and glutathione reductase decrease with advanced age in various tissues. We have examined the effects of donor age on erythrocyte and lymphocyte levels of these three parameters in human subjects. The results indicate that glutathione content, and(More)
The arylhydrazines 4-methylphenylhydrazine hydrochloride, N'-acetyl-4-methylphenylhydrazine and N'-acetyl-4-hydroxymethylphenylhydrazine (HMPH) were metabolized by ram seminal vesicle prostaglandin(H)synthase (P(H)S) and by cytochrome P-450- and P(H)S-dependent enzymes from mouse lung. Based on the Km-values, the cytochrome P-450 enzymes were the most(More)
PURPOSE Several clinical trials have highlighted general favorable outcomes of intravenous tissue type plasminogen activator (rt-PA) in acute ischemic stroke using different measures including, National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). Findings from most of these measures indicate that the benefits of rt-PA are time(More)
Female mice between the ages of 1–18 months were treated with 50 mg oltipraz/kg by intragastric tube every other day for 5 doses. At all ages, oltipraz resulted in significant increases in hepatic glutathione content and glutathione reductase and glutathione S-transferase activities. Oltipraz also produced decreases in hepatic DNA damage (single strand(More)