Terrence C. Dahl

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Phosphonate analogs of nucleotides have recently received considerable attention as potential antiviral agents. The ionic character of these agents limits their permeability across the human intestinal mucosa, resulting in low bioavailability after oral administration (1,2). We have previously demonstrated the utility of the bis-isopropyloxycarbonylmethyl(More)
Purpose. The chemical stability and product(s) distribution of adefovir dipivoxil (ADV) was examined in the presence of soluble and insoluble carbonate salts. Methods. Chemical stability of ADV in the solid state at 60°C/30% RH was examined. Stability was also examined in the presence of excess formaldehyde vapor at 23°C/53% RH. ADV and its degradation(More)
The mass transport of two different compounds through polydi-methylsiloxane (PDMS)–silica films was investigated to demonstrate qualitatively how this coating system can alter the release of various compounds. Various ratios of PDMS elastomer and silica were used to coat monodisperse particle-sized pellets layered with an ionizable compound (tartrazine) and(More)
Purpose. To examine the degradation kinetics and identify the degradation products of a neuraminidase inhibitor prodrug, GS-4104. Methods. Degradation was studied as a function of pH and temperature using a stability-indicating RP-HPLC assay. Degradation products were isolated by RP-HPLC and identified by NMR. Specific rate constants were calculated based(More)
Pediatric oral formulations can be quite scientifically challenging to develop and the prerequisites for both a measurable dosage form to administer based upon bodyweight, and also taste-masking are two of the challenges unique for pediatric oral formulations. The physicochemical and organoleptic properties of the active drug substance such as solubility,(More)
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