Terrell L. Hill

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  • T L Hill
  • Proceedings of the National Academy of Sciences…
  • 1985
A possible model is analyzed for the maintenance of attachment of a shortening microtubule (MT) to a kinetochore. In this model it is assumed that a MT is inserted and held in a sleeve or channel of the outer layer of a kinetochore while subunits are lost from the MT tip through the central layer of the kinetochore. A second problem considered is the(More)
Recent experimental data on the equilibrium binding of myosin subfragment 1 (S-1) to regulated actin filaments in the presence and in the absence of Ca(2+) are analyzed by using a linear Ising model. In the model, each tropomyosin-troponin unit (including seven sites on the actin filament) can be in one of two possible states, which have different intrinsic(More)
We recently presented, in a qualitative manner, a cross-bridge model of muscle contraction which was based on a biochemical kinetic cycle for the actomyosin ATPase activity. This cross-bridge model consisted of two cross-bridge states detached from actin and two cross-bridge states attached to actin. In the present paper, we attempt to fit this model(More)
  • T L Hill, Y Chen
  • Proceedings of the National Academy of Sciences…
  • 1972
Empirical functions, such as n(infinity)(V) and tau(n)(V) (of the Hodgkin-Huxley type), can be recast in terms of more fundamental functions F(V) (related to a conformational free energy change) and theta(V) (related to the corresponding free energies of activation). Examples of F(V) and theta(V) are given, for squid and frog node. F(V) is essentially a(More)
Under conditions where microtubule nucleation and growth are fast (i.e., high magnesium ion and tubulin concentrations and absence of glycerol), microtubule assembly in vitro exhibits an oscillatory regime preceding the establishment of steady state. The amplitude of the oscillations can represent greater than 50% of the maximum turbidity change and(More)
  • T L Hill
  • Proceedings of the National Academy of Sciences…
  • 1981
Microtubules (tubulin) or bundles of microfilaments (actin) are thought to cause movement, in some instances, by disassembly or assembly of subunits. Possible examples are the pulling of a chromosome toward a pole in mitosis (anaphase) or the deformation of a cell membrane to change the shape of a cell. This paper examines the relevant elementary(More)
It is shown by use of an extremely simple explicit two-state model that two basic ideas may be sufficient to understand at least qualitatively the sensitive activation of isometric muscle contraction by Ca2+. (a) Ca2+ binds much more strongly on troponin if myosin is already attached to actin. The steady state analogue of this is that the single rate(More)