Tereza Benesova

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Infrared A (IRA) radiation (760-1440 nm) is a major component of solar radiation and, similar to UVR, causes photoaging of human skin by increasing the expression of matrix metalloproteinase-1 in human skin fibroblasts. In this study, we assessed the IRA-induced transcriptome in primary human skin fibroblasts. Microarray analysis revealed 599 IRA-regulated(More)
IRA accounts for one third of the solar energy reaching the earth's surface and penetrates deeply into the human skin. Previous studies of our group have shown that IRA in HDF induces a retrograde signaling cascade involving mitochondrial reactive oxygen species (ROS) and, via involvement of the MAP-kinases ERK 1/2, alters gene expression. Among the genes(More)
Gene expression analysis was performed utilizing Affymetrix DNA-microarrays, realtime PCR and Western Blot. To identify differentially regulated genes despite a bias due to interindividual differences in gene expression, we applied a filtering strategy, which selects genes regulated in at least three of nine independent experiments performed, revealing 599(More)
Solar radiation is well known to damage human skin, for example by causing premature skin ageing (i.e. photoageing). We have recently learned that this damage does not result from ultraviolet (UV) radiation alone, but also from longer wavelengths, in particular near-infrared radiation (IRA radiation, 760-1,440 nm). IRA radiation accounts for more than one(More)
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