This study addresses the prevalence of ATM mutations and the association with breast cancer in Austrian families selected for a history of breast or ovarian cancer or both [hereditary breast and ovarian cancer (HBOC)]. In 270 HBOC families previously screened for BRCA1 and BRCA2 mutations, 137 different sequence alterations of ATM were identified. Seven of… (More)
analysis of the BRCA1 and BRCA2 genes has become widely available to hereditary breast and ovarian cancer families (HBOC) or breast-cancer-only families (HBC) in North America and Europe. To date, hundreds of these families have been identified with BRCA mutations and the majority has received counselling regarding the test results. Follow-up care of… (More)
We studied residents of remote villages and the capital (Port Moresby) of Papua New Guinea to determine the distribution of human herpesvirus-8 (HHV-8) infection. Our data suggest that HHV-8 has been endemic on the island for a long time and that the epidemiologic pattern of HHV-8 is more similar to that of herpes simplex virus-2 than hepatitis C virus.
OBJECTIVE The aim of our study was to perform an immunohistochemical and ultrastructural analysis of the nuclear architecture of cardiomyocytes from an end-stage DCM patient with a missense point mutation in the exon 3 of the LMNA gene which is predicted to result in a D192G substitution. METHODS We studied endomyocardial biopsy samples taken from the… (More)
Mice were used at 4–8 weeks old. Local field potentials (EVG) were recorded from the luminal surface of intact VNO sensory epithelia 9. 2,5-dimethylpyrazine, 2-heptanone, n-pentyl acetate and isobutylamine were purchased from Aldrich; 2-sec-butyl-4,5-dihydrothiazole from Alfa Aesar; and farnesene from Bedoukian Research. Sequence analysis of mouse… (More)