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Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line
TLDR
Berberine displays multiphasic effects in these malignant cell lines, which are correlated with the concentration and intracellular distribution of this alkaloid, and suggest that its use in clinical development may be more as a cytostatic agent than a cytotoxic compound. Expand
Lipophilic caffeic and ferulic acid derivatives presenting cytotoxicity against human breast cancer cells.
TLDR
The results show that the new caffeic and ferulic acid lipophilic derivatives show increased cytotoxicity toward human breast cancer cell lines, although the magnitude and type of effects appear to be dependent on the cell type. Expand
Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells--nuclear vs. mitochondrial effects.
TLDR
It is suggested that Sang is able to induce apoptosis in metastatic melanoma cells, and the knowledge of mitochondrial vs. nuclear effects of SANG is important in the development of this promising compound for clinical use against aggressive melanoma. Expand
Berberine as a promising safe anti-cancer agent - is there a role for mitochondria?
TLDR
Evidence is supplied that berberine is a safe anti-cancer agent, exerting several effects on mitochondria, including inhibition of mitochondrial Complex I and interaction with the adenine nucleotide translocator which can explain several of the described effects on tumor cells. Expand
Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
TLDR
It is shown that pyrimidine biosynthesis dependent on respiration-linked dihydroorotate dehydrogenase (DHODH) is required to overcome cell-cycle arrest, while mitochondrial ATP generation is dispensable for tumorigenesis, pointing to inhibitors of DHODH as potential anti-cancer agents. Expand
Cardiomyocyte H9c2 cells present a valuable alternative to fish lethal testing for azoxystrobin.
TLDR
The H9c2 cell-based assay is reliable and represents a suitable ethical alternative to conventional fish assays for AZX, and could be used to get valuable insights into the toxic effects of other pesticides. Expand
Role of mtDNA‐related mitoepigenetic phenomena in cancer
TLDR
The often disregarded mitochondrial epigenetic landscape provides an additional source of deregulation that may contribute to carcinogenesis. Expand
From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia.
TLDR
The current knowledge on the external stimuli and cell-intrinsic lesions that drive aberrant activation of pivotal, pro-tumoral intracellular signaling pathways in T-cell precursors, driving transformation, leukemia expansion, spread or resistance to therapy is summarized. Expand
Analysis of pro-apoptotic protein trafficking to and from mitochondria.
TLDR
The procedures that can be used to study the subcellular location of different pro-apoptotic proteins to be used in basic cell biology and toxicology studies are described. Expand
Metabolic and Phenotypic Characterization of Human Skin Fibroblasts After Forcing Oxidative Capacity
TLDR
The results showed that forcing mitochondrial remodeling in human skin fibroblasts increased oxygen consumption rate, ATP levels, and mitochondria-related transcripts and proteins, and the metabolic remodeling increased cytotoxicity of mitochondrial poisons. Expand
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