Teresa Connolly

Learn More
A cDNA library prepared from a human glioblastoma cell line has been introduced into a budding yeast strain that lacks CLN1 and CLN2 and is conditionally deficient for CLN3 function. We rescued a gene that we call cyclin D1. It is related to A-, B-, and CLN-type cyclins, but appears to define a new subclass within the cyclin gene family. Transcription of(More)
In this report, we describe the cloning and characterization of a B-type cyclin, Cig2 from the fission yeast Schizosaccharomyces pombe. The cig2 gene encodes a 45-kDa protein that is most similar to a previously identified B-type cyclin in S. pombe, Cdc13. Deletion of cig2 had no observable effect on cell viability or progression through the cell cycle.(More)
Methotrexate transport deficiency due to decreased reduced folate carrier (RFC) activity has been observed in several cell lines selected for resistance to methotrexate (MTX). Since MTX resistance is multifactorial, however, it is difficult to quantify the relative importance of changes in RFC activity in selected cell lines and even more so to determine(More)
In the fission yeast Schizosaccharomyces pombe, the execution of Start requires the activity of the Cdc2 protein kinase and the Cdc10/Sct1 transcription complex. The loss of any of these genes leads to G1 arrest and activation of the mating pathway under appropriate conditions. We have undertaken a genetic and biochemical analysis of these genes and their(More)
Open educational resources (OER) have recently emerged as an answer to the need for open and reusable educational material, freely available online. Educational institutions, private organisations, as well as individual learners and educators have embraced the OER initiative. Bringing these stakeholders together and supporting them in collaboratively(More)
This chapter introduces a widget-based Personal Learning Environment (PLE) specifically designed for finding and sharing Open Educational Resources (OER) on the web. COLEARNING OBJECTIVES The aim of this investigation is to raise awareness about the capabilities of widget-based PLEs to researchers, educators and learners that are interested in finding and(More)
Copyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copyright owners. For more information on Open Research Online's data policy on reuse of materials please consult the policies page. Abstract. Personal Learning Environments (PLEs) hold the potential to address the needs of informal learners for(More)
We have undertaken a biochemical analysis of the regulation of the G1/S-phase transition and commitment to the cell cycle in the fission yeast Schizosaccharomyces pombe. The execution of Start requires the activity of the Cdc2 protein kinase and the Sct1/Cdc10 transcription complex. Progression through G1 also requires the Ran1 protein kinase whose(More)
—Self-regulated learning (SRL) is a term that describes an individual's ability to learn how to learn. New pedagogical theories encourage teachers to motivate and support their students into achieving a high level of self-regulation in their learning. This paper reports on the preliminary findings of a survey that was conducted with educators in the UK and(More)