Teresa Brugman

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The validity of the single breath helium dilution method for accurate measurement of the total lung capacity (TLC) was investigated. Comparison was made with the multiple breath nitrogen equilibration technique in 22 normal subjects and 37 patients with chronic obstructive pulmonary disease (COPD). The single breath method underestimated the TLC in all the(More)
These studies suggest that the immunologic indicator in the radioimmune assay, 125I-iodoinsulin, selects antibody populations from within the antiserum that interact with determinants distant from the solvent surface on the insulin molecule to which iodine is substituted. Evidence is presented that the connecting peptide of proinsulin is in close proximity(More)
Leukotriene D4 (5 micrograms/ml) aerosol constricts airways of dogs with nonspecific airway hyperreactivity but not of mongrel dogs which lack nonspecific airway hyperreactivity. RL increased 200 +/- 25% and Cdyn decreased to 77 +/- 5% of the prechallenge value. LTD4 (10 micrograms/ml) produced no further increase. Atropine (0.2 mg/kg) prevented the(More)
We investigated the ability of a calcium channel blocker nifedipine, given as an aerosol, to attenuate bronchoconstriction induced by citric acid, Ascaris antigen, and methacholine in Basenji-Greyhound dogs. citric acid 10% increased pulmonary resistance (RL) 4.2-fold +/- 1.0 (mean +/- SEM) and 1.7-fold +/- 0.7 in untreated and nifedipine-pretreated dogs (P(More)
Comparison of c.d. spectra of Zn-insulin with Zn2+-free insulin demonstrated significant differences. It has been proposed that these differences are due to either changes in the structure of insulin monomers within aggregated insulins or the results of insulin aggregation. The effect of Zn2+ on the immunological activity of insulin indicated that the(More)
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