Terence Tan

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Class 3 semaphorins are well-known axonal guidance cues during the embryonic development of mammalian nervous system. However, their activity on postnatally differentiated neurons in neurogenic regions of adult brains has not been characterized. We found that silencing of semaphorin receptors neuropilins (NRP) 1 or 2 in neural progenitors at the adult mouse(More)
BACKGROUND Over-expression of cyclooxygenase-2 (COX-2) enzyme has been reported in nasopharyngeal carcinoma (NPC). However, the prognostic significance of this has yet to be conclusively determined. Thus, from our randomized trial of radiation versus concurrent chemoradiation in endemic NPC, we analyzed a cohort of tumour samples collected from participants(More)
Excitotoxicity is a major mechanism of neuronal damage in cerebral ischemia and is mediated largely by neuronal N-methyl-D-aspartate receptors (NMDAR). This review presents the structural and functional alterations in NMDAR after an ischemic insult, including the antagonistic roles different NMDAR sub-types play in the post-ischemic period. By elucidating(More)
This paper briefly introduces an information systems development/acquisition method, FOOM Swatman & Swatman (1992a) and justifies the need for computerised support for the method prior to further field trials. The paper then describes the requirements of a workbench which may be used to support FOOM and reports the experience gained in using FOOM itself in(More)
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