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PURPOSE Tumour hypoxia is thought to play a significant role in the outcome of solid tumour therapy. Positron emission tomography (PET) is the best-validated noninvasive technique able to demonstrate the presence of hypoxia in vivo. The locally developed PET tracer for imaging hypoxia, 1-alpha-D: -(5-deoxy-5-[(18)F]-fluoroarabinofuranosyl)-2-nitroimidazole(More)
Continued therapeutic gain in the treatment of non-small-cell lung cancer (NSCLC) will depend upon our ability to escalate the dose to the primary tumour while minimizing normal tissue toxicity. Both these objectives are facilitated by the accurate definition of a target volume that is as small as possible. To this end, both tumour immobilizations via deep(More)
AIM Positron emission tomography (PET) has been used increasingly in the staging and radiotherapy treatment planning of non-small-cell lung cancer (NSCLC). This study investigates the factors that affect the resultant size of a given image on PET. METHODS PET was used to assess the geometric characteristics of a series of radioisotope-filled, stationary(More)
We introduce an interacting random-walk model to describe the residence time of drug molecules undergoing a series of sojourn times in the body before being permanently eliminated under either homogeneous or heterogeneous conditions. We show that short-term correlations between drug molecules lead to Michaelis-Menten kinetics while long-term correlations(More)
Lung cancer represents the most deadly type of malignancy. In this work we propose a machine learning approach to segmenting lung tumours in Positron Emission Tomography (PET) scans in order to provide a radiation therapist with a " second reader " opinion about the tumour location. For each PET slice, our system extracts a set of attributes, passes them to(More)
UNLABELLED PURPOSE. This article reports the pharmacokinetics, radiation dosimetry and radioimmunoscintigraphy (RIS) of two (99m)Tc-labelled monoclonal antibodies (MAb) used to detect cancer. METHODS The effects of circulating antigen in female cancer patients are explored and their effects on the ability of these MAbs to effectively perform as RIS agents(More)
BACKGROUND The standard treatment of high grade gliomas (HGG) involves maximal neuro-surgical debulking, followed by post-operative radiotherapy, with or without concurrent chemotherapy, depending on histologic grade. Despite this aggressive strategy, there are few long-term survivors. Proton magnetic resonance spectroscopy (MRS) is a non-invasive imaging(More)
An analytical theory of photon propagation and detection in single-photon emission computed tomography (SPECT) for collimated detectors is developed from first principles. The total photon detection kernel is expressed as a sum of terms due to the primary and the Compton scattered photons. The primary as well as contributions due to every order of Compton(More)
Compared with slice-by-slice approaches for SPECT reconstruction, three-dimensional iterative methods provide a more accurate physical model and an improved SPECT image. Clinical application of these methods, however, is limited primarily to their computational demands. This paper investigates the methods for approximate 3D iterative reconstruction that(More)
In recent years, a number of approaches have been applied to the problem of deformable registration validation. However, the challenge of assessing a commercial deformable registration system - in particular, an automatic registration system in which the deformable transformation is not readily accessible - has not been addressed. Using a collection of(More)