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Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides.
TLDR
Characterization of giant modular polyketide synthases (PKSs) responsible for the production of aminopolyol polyketides and phylogenetic analysis of highly homologous but functionally diverse domains from the giant PKSs demonstrated the evolutionary mechanism for structural diversification ofpolyketides.
Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi.
TLDR
The biosynthetic machinery of the first fungal ribosomally synthesized and post-translationally modified peptide (RiPP) ustiloxin B was elucidated through a series of gene inactivation and heterologous expression studies, providing new insight into the expression of the RiPP gene clusters found in various fungi.
JBIR-94 and JBIR-125, antioxidative phenolic compounds from Streptomyces sp. R56-07.
TLDR
Two phenolic compounds were isolated from the fermentation broth of strain R56-07, which was identified by phylogenetic methods as a novel species of Streptomyces, and are the first examples of hydroxycinnamic acid amides containing putrescine or spermidine produced by actinomycetes.
Three eremophilane derivatives, MBJ-0011, MBJ-0012 and MBJ-0013, from an endophytic fungus Apiognomonia sp. f24023
Three eremophilane derivatives, MBJ-0011, MBJ-0012 and MBJ-0013, from an endophytic fungus Apiognomonia sp. f24023
Mechanism of Action of Prethioviridamide, an Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptide with a Polythioamide Structure.
TLDR
Results imply that the members of a unique family of RiPPs with polythioamide structure target mitochondria to induce the integrated stress response (ISR) through the GCN2-ATF4 pathway, which is likely to cause cell death.
JBIR-137 and JBIR-138, new secondary metabolites from Aspergillus sp. fA75
TLDR
To achieve this, the highthroughput detection system for microbial secondary metabolites using UPLC-UV-evaporative light-scattering (ELS)-MS system was established, and more than 1000 compounds, which have already been isolated, were analyzed by the common analytic method and in the database.
JBIR-120: a new growth inhibitor of hormone-refractory prostate cancer cells
TLDR
A novel compound is discovered—JBIR-120 (1)—extracted from the culture broth of a new Streptomyces strain, RI104-LiC104, which may possibly control the occurrence of hormone-refractory prostate cancers.
Neothioviridamide, a Polythioamide Compound Produced by Heterologous Expression of a Streptomyces sp. Cryptic RiPP Biosynthetic Gene Cluster.
TLDR
The cloning and heterologous expression of the neothioviridamide biosynthetic gene cluster is reported and the isolation, structure determination, and cytotoxic activity of neothioamide is reported.
Absolute configuration of chlorosulfolipids from the chrysophyta Ochromonas danica.
TLDR
Eight chlorosulfolipids (1-8) were isolated from the chrysophyta Ochromonas danica (IAM CS-2), including five new chloro-chloro-14-docosanol-1-sulfate (2), which was the most toxic to brine shrimp (Artemia salina) larvae.
Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.
Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp(3) carbons in the 10-membered ring had chirality, which
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