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Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by extracellular β-amyloid (Aβ) plaques and intracellular neurofibrillary tangles in the brain. Aβ aggregation is closely associated with neurotoxicity, oxidative stress, and neuronal inflammation. The soluble Aβ oligomers are believed to be the most neurotoxic form among all(More)
Nanoelectronics research has primarily focused on devices. By contrast, not much has been published on innovations at higher layers: we know little about how to construct circuits or architectures out of such devices. In this paper, we focus on the currently most promising nanodevice technologies, such as arrays of semiconductor nanowires (NWs) and arrays(More)
MapReduce is a widely accepted framework for addressing big data challenges. Recently, it has also gained broad attention from scientists at the U.S. leadership computing facilities as a promising solution to process gigantic simulation results. However, conventional high-end computing systems are constructed based on the compute-centric paradigm while big(More)
T-box 18 (TBX18) plays a crucial role in the formation and development of the head of the sinoatrial node. The objective of this study was to induce adipose-derived stem cells (ADSCs) to produce pacemaker-like cells by transfection with the TBX18 gene. A recombinant adenovirus vector carrying the human TBX18 gene was constructed to transfect ADSCs. The(More)
Pork is known as one of the most important sources of Toxoplasma gondii infection in China. In the present study, 416 fresh pork samples were collected from different locations of Anhui province, Eastern China. Tissue fluid ELISA was conducted to detect the antibodies to T. gondii. Real-time PCR and bioassay were performed to identify the presence of T.(More)
Most of the research in the field of nanoelectronics has been focused on nanodevices and fabrication aspects and as a result a variety of nanodevice technologies have been demonstrated. By contrast, very little work has been reported on the design and evaluation of circuits and computational architectures using nano-devices. There is similarly not much work(More)
A new hybrid CMOS-nanoscale circuit style has been developed that uses only one type of Field Effect Transistor (FET) in the logic portions of a design. This is enabled by CMOS providing control signals that coordinate the operation of the logic implemented in the nanoscale. In this paper, the new circuit style is explored, examples from a microprocessor(More)
—By means of the permanent scatterer (PS) technique, repeated spaceborne synthetic aperture radar (SAR) images with relatively low resolution (about 25 m × 5 m for the European Remote Sensing (ERS) and Envisat satellites) can be used to estimate the displacement (1-mm precision) and 3-D location (1-m precision) of targets that show an unchanged(More)
UNLABELLED Polydopamine-based surface modification is a simple way to functionalize polymeric nanoparticle (NP) surfaces with ligands and/or additional polymeric layers. In this work, we developed DTX-loaded formulations using polydopamine-modified NPs synthesized using D-α-tocopherol polyethylene glycol 1000 succinate-poly(lactide) (pD-TPGS-PLA/NPs). To(More)