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Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by extracellular β-amyloid (Aβ) plaques and intracellular neurofibrillary tangles in the brain. Aβ aggregation is closely associated with neurotoxicity, oxidative stress, and neuronal inflammation. The soluble Aβ oligomers are believed to be the most neurotoxic form among all(More)
Nanoelectronics research has primarily focused on devices. By contrast, not much has been published on innovations at higher layers: we know little about how to construct circuits or architectures out of such devices. In this paper, we focus on the currently most promising nanodevice technologies, such as arrays of semiconductor nanowires (NWs) and arrays(More)
BmTXKbeta, a scorpion toxin isolated from the Chinese scorpion Buthus martensii Karsch (BmK), was expressed as a GST fusion protein in BL21 (DE3) strain. The recombinant GST-BmTXKbeta protein was purified by affinity chromatography. When treated with enterokinase, the GST-BmTXKbeta fusion protein released an approximate 6.5kDa protein which was the expected(More)
MapReduce is a widely accepted framework for addressing big data challenges. Recently, it has also gained broad attention from scientists at the U.S. leadership computing facilities as a promising solution to process gigantic simulation results. However, conventional high-end computing systems are constructed based on the compute-centric paradigm while big(More)
The rapid progress of manufacturing nanoscale devices is pushing researchers to explore appropriate nanoscale computing architectures for high density beyond the physical limitations of conventional lithography. However, manufacturing and layout constraints, as well as high defect/fault rates expected in nanoscale fabrics, could make most device density(More)
With recent promising progress on nanoscale devices including semiconductor nanowires and nanowire crossbars, researchers are trying to explore the possibility of building nanoscale computing systems. We have designed a nanoscale application-specific architecture called NASIC, which is based on semiconductor nanowire grids and FETs at crosspoints. In this(More)
A new hybrid CMOS-nanoscale circuit style has been developed that uses only one type of Field Effect Transistor (FET) in the logic portions of a design. This is enabled by CMOS providing control signals that coordinate the operation of the logic implemented in the nanoscale. In this paper, the new circuit style is explored, examples from a microprocessor(More)
Levels of microplastics (MPs) in China are completely unknown. This study characterizes suspended MPs quantitatively and qualitatively for the Yangtze Estuary and East China Sea. MPs were extracted via a floatation method. MPs were counted and categorized according to shape and size under a stereomicroscope. The MP densities were 4137.3±2461.5 and(More)
Most of the research in the field of nanoelectronics has been focused on nanodevices and fabrication aspects and as a result a variety of nanodevice technologies have been demonstrated. By contrast, very little work has been reported on the design and evaluation of circuits and computational architectures using nanodevices. There is similarly not much work(More)