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- Tema Fridman, Jane Razumovskaya, Nathan Verberkmoes, Gregory B. Hurst, Vladimir Protopopescu, Ying Xu
- J. Bioinformatics and Computational Biology
- 2005

Proteomic techniques are fast becoming the main method for qualitative and quantitative determination of the protein content in biological systems. Despite notable advances, efficient and accurate analysis of high throughput proteomic data generated by mass spectrometers remains one of the major stumbling blocks in the protein identification problem. We… (More)

We have constructed fully self-consistent models of triaxial galaxies with central density cusps. The triaxial generalizations of Dehnen’s (1993) spherical mass models are presented, which have densities that vary as r near the center and r at large radii. We computed libraries of ∼ 7000 orbits in each of two triaxial models with γ = 1 (“weak cusp”) and γ =… (More)

Recent work on the equilibrium and stability of ellipsoidal stellar systems is reviewed. The absence of constant-density cores in early-type galaxies implies that chaos and high-order resonances are generic features of the motion in triaxial stellar systems. Bending instabilities are now well understood and may provide the answers to a number of… (More)

The orbital structure of triaxial models with weak central density cusps, ρ ∝ r, γ < 1, is investigated. The stability of the x(long-) axis orbit – and hence the existence of box orbits – depends sensitively on γ; the range of model shapes for which the x-axis orbit is stable becomes progressively smaller as γ approaches one. The banana and fish boxlets in… (More)

- I D BOIKO, R D SOIFER, T I FRIDMAN
- Meditsinskaia promyshlennost' SSSR
- 1962

- Tema Fridman, Vladimir Protopopescu, Greg Hurst, Andrei Borziak, Andrey Gorin
- Omics : a journal of integrative biology
- 2005

We derive the optimal number of peaks (defined as the minimum number that provides the required efficiency of spectra identification) in the theoretical spectra as a function of (i) the experimental accuracy, sigma, of the measured ratio m/z; (ii) experimental spectrum density; (iii) size of the database; (iv) number of peaks in the theoretical spectra; and… (More)

- Andrey Gorin, Robert M. Day, Andrey Borziak, Michael B. Strader, Gregory B. Hurst, Tema Fridman
- Proceedings. 2004 IEEE Computational Systems…
- 2004

Tandem mass spectrometry (MS/MS) is one of the leading proteomics technologies, applicable to a wide range of experiments involving composition analysis of protein mixtures. Currently only /spl sim/10-20% of MS/MS spectral data lead to the successful peptide identifications, and the rate of false positives remains to be high. We propose probability profile… (More)

- Tema Fridman, Robert M. Day, Jane Razumovsbya, Dong Xu, Andrey Gorin
- CSB
- 2003

A novel method is proposed for deciphering experimental tandem mass spectra. A large database of previously resolved peptide spectra was used to determine “neighborhood patterns” for each peak category: Cor N-terminus ions, their dehydrated fragments, etc. The established patterns are applied to assign probabilities for new spectra peaks to fit into these… (More)

- Nikita Arnold, Tema Fridman, Robert M. Day, Andrey Gorin
- ISBRA
- 2008

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