Tema Fridman

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Proteomic techniques are fast becoming the main method for qualitative and quantitative determination of the protein content in biological systems. Despite notable advances, efficient and accurate analysis of high throughput proteomic data generated by mass spectrometers remains one of the major stumbling blocks in the protein identification problem. We(More)
A novel method is proposed for deciphering experimental tandem mass spectra. A large database of previously resolved peptide spectra was used to determine " neighborhood patterns " for each peak category: C-or N-terminus ions, their dehydrated fragments, etc. The established patterns are applied to assign probabilities for new spectra peaks to fit into(More)
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