Telmo Amaral

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The overall purpose of the research discussed here is the enhancement of home-based care by revealing individual patterns in the life of a person, through modelling of the "busyness" of activity in their dwelling, so that care can be better tailored to their needs and changing circumstances. The use of data mining and on-line analytical processing (OLAP) is(More)
Breast tissue microarrays facilitate the survey of very large numbers of tumours but their scoring by pathologists is time consuming, typically highly quantised and not without error. Automated seg-mentation of cells and intra-cellular compartments in such data can be problematic for reasons that include cell overlapping, complex tissue structure, debris,(More)
Breast tissue microarrays (TMAs) facilitate the study of very large numbers of breast tumours in a single histological section, but their scoring by pathologists is time consuming, typically highly quantised, and not without error. This paper compares the results of different classification and ordinal regression algorithms trained to predict the scores of(More)
Tissue microarrays have become an important tool in clinical research to analyse molecular and protein markers in various types of cancer. However their analysis is a time-consuming task and introduces inter-and intra-observer variations. An automated method is proposed, called spin-context, to segment in-situ and invasive tumour regions in images of breast(More)
Deep neural networks comprise several hidden layers of units, which can be pre-trained one at a time via an unsupervised greedy approach. A whole network can then be trained (fine-tuned) in a supervised fashion. One possible pre-training strategy is to regard each hidden layer in the network as the input layer of an auto-encoder. Since auto-encoders aim to(More)
A method for automatic segmentation of tumour regions in breast histopathology images is described. It uses auto-context to label pixels based on local image features and contextual label probabilities. We propose spin-context to compute context features that are invariant under image rotation. Quantitative evaluation is reported using spots stained for(More)
BACKGROUND Tissue microarrays (TMAs) are an important tool in translational research for examining multiple cancers for molecular and protein markers. Automatic immunohistochemical (IHC) scoring of breast TMA images remains a challenging problem. METHODS A two-stage approach that involves localization of regions of invasive and in-situ carcinoma followed(More)
Deep architectures have been used in transfer learning applications, with the aim of improving the performance of networks designed for a given problem by reusing knowledge from another problem. In this work we addressed the transfer of knowledge between deep networks used as classifiers of digit and shape images, considering cases where only the set of(More)
Tissue microarrays (TMAs) facilitate the survey of very large numbers of tumors. However, the manual assessment of stained TMA sections constitutes a bottleneck in the pathologist's work flow. This paper presents a computational pipeline for automatically classifying and scoring breast cancer TMA spots that have been subjected to nuclear immunostaining.(More)