Telma França Padilha

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Chronic myeloid leukemia (CML) is a myeloproliferative disorder, characterized by the presence of the Philadelphia (Ph) chromosome, a consequence of a reciprocal translocation between chromosomes 9 and 22, resulting in the fusion of the genes BCR and ABL. The BCR–ABL fusion gene encodes a constitutively active leukemogenic protein tyrosine kinase. BCR–ABL(More)
SCT such as BMT or cord blood transplantation (CBT) is an effective therapy for hematological malignancies. Nevertheless, there are still serious problems associated with SCT, such as secondary malignancy and relapse. Both chemotherapy and radiation for conditioning regimen before SCT are thought to be causes of genomic instability. Occasionally, they(More)
Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7(More)
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