Teka Khan

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Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels.

Shi Yin, Xiaohua Jiang, +12 authors Qinghua Shi
Development
2017

Proper oocyte development is crucial for female fertility and requires timely and accurate control of gene expression. K (lysine) acetyltransferase 8 (KAT8), an important component of the X… (More)

RPL10L Is Required for Male Meiotic Division by Compensating for RPL10 during Meiotic Sex Chromosome Inactivation in Mice

Long Jiang, Tao Li, +14 authors Qinghua Shi
Current Biology
2017

The mammalian sex chromosomes have undergone profound changes during their evolution from an ancestral pair of autosomes [1-4]. Specifically, the X chromosome has acquired a paradoxical sex-biased… (More)

The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2 are dispensable for fertility in mice

Manan Khan, Nazish Jabeen, +11 authors Qinghua Shi
Scientific Reports
2018

There are more than 2300 genes that are predominantly expressed in mouse testes. The role of hundreds of these genes has been studied in mouse spermatogenesis but still there are many genes whose… (More)

Whole exome sequencing identifies a novel dominant missense mutation underlying leukonychia in a Pakistani family

Teka Khan, Manan Khan, +12 authors Huan Zhang
Journal of Human Genetics
2018

Hereditary leukonychia (also known as porcelain nails or white nails) is a genetic disorder. It may exist as an isolated feature or associated with other cutaneous or systemic disorders. Although a… (More)

MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice

Hanwei Jiang, Qian Gao, +12 authors Qinghua Shi
PLoS genetics
2018

Three waves of H2AX phosphorylation (γH2AX) have been observed in male meiotic prophase I: the first is ATM-dependent and occurs at leptonema, while the second and third are ATR-dependent, occuring… (More)

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