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Exosomes are naturally occurring nanosized vesicles that have attracted considerable attention as drug delivery vehicles in the past few years. Exosomes are comprised of natural lipid bilayers with the abundance of adhesive proteins that readily interact with cellular membranes. We posit that exosomes secreted by monocytes and macrophages can provide an(More)
Environmental heat illness and injuries are a serious concern for the Army and Marines. Currently, the Wet-Bulb Globe Temperature (WBGT) index is used to evaluate heat injury risk. The index is a weighted average of dry-bulb temperature (Tdb), black globe temperature (Tbg), and natural wet-bulb temperature (Tnwb). The WBGT index would be more widely used if(More)
Approved for public release; distribution is unlimited. ABSTRACT Gait asymmetry can be a useful indicator of a variety of medical and pathological conditions, including musculoskeletal injury (MSI), neurological damage associated with stroke or head trauma, and a variety of age-related disorders. Body-worn accelerometers provide the ability for real-time(More)
The purpose of this paper is to develop a database of tissue composition, distribution, volume, surface area, and skin thickness from anatomically correct human models, the virtual family. These models were based on high-resolution magnetic resonance imaging (MRI) of human volunteers, including two adults (male and female) and two children (boy and girl).(More)
Gait asymmetry can be a useful indicator of a variety of medical and pathological conditions, including musculoskeletal injury (MSI), neurological damage associated with stroke or head trauma, and a variety of age-related disorders. Body-worn accelerometers can enable real-time monitoring and detection of changes in gait asymmetry, thereby informing medical(More)
A wearable oximeter is needed to help people safely perform missions in environmental extremes. Key initial needs are to monitor for hypoxemia at high altitudes, and to monitor for shock in the event of trauma and hemorrhage. An initial investigation has been performed to assess design parameters for a wearable oximeter. Initial data was collected to assess(More)
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