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Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation. We compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip. We identified 12 genome-wide significant(More)
We discuss potential market mechanisms for the GRID. A complete dynamical model of a GRID market is defined with three types of agents. Providers, middlemen and users exchange universal GRID computing units (GCUs) at varying prices. Providers and middlemen have strategies aimed at maximizing profit while users are 'satisficing' agents, and only change their(More)
—Video streaming from sensors and miniaturized devices is attractive for a wide range of web-based applications, e.g., remote surveillance. Existing web-based video streaming frameworks, such as the hypertext transfer protocol (HTTP) live streaming (HLS) and the motion picture experts group's dynamic adaptive streaming over HTTP (MPEG-DASH), have(More)
The Requirement Engineering (RE) is a systemic and integrated process of eliciting, elaborating, negotiating, prioritizing, specifying, validating and managing the requirements of a system. The detailed and agreed requirements are documented and specified to serve as the basis for further system development activities. The software industry has moved from(More)
  • Rupali S Vairagade, Tejas Shah, Tejas Chavan, Rohan Bhatt
  • 2016
Market Basket Analysis is a technique to identify items likely to be purchased together. A predictive market basket analysis is used to identify sets of products/services purchased or events that occur generally in sequence. The basic approach is to find the associated pairs of items in a store when there are transaction data sets. Hence, our proposed(More)
Progressive retinal atrophy (PRA) is one of the major causes of retinal photoreceptor cell degeneration in canines. The inheritance pattern of PRA is autosomal recessive and genetically heterogeneous. Here, using targeted sequencing technology, we have performed exome sequencing of 10 PRA-affected (Spitz = 7, Cocker Spaniel = 1, Lhasa Aphso = 1 and(More)
Asthma is a chronic inflammatory disorder delineated by a heightened immunological response due to environmental or genetic factors. Single nucleotide polymorphism studies have shown that FOXO3a plays a pivotal role in maintaining immunoregulation. Polymorphism in FOXO3a has been linked to inflammatory diseases such as chronic obstructive pulmonary disease(More)
Cardiovascular diseases (CVDs) deserve more clinical attention being the primary clinical outcome of metabolic syndrome (MetS). Indians are highly predisposed to MetS, insulin resistance and CVDs. The traditional and unconventional risk factors in circulation could prove to be of immense value in further CVD risk stratification. Lipoprotein(a) [Lp(a)] and(More)