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OBJECTIVE To evaluate the genetic contribution to schizophrenia using an adoption design that disentangles genetic and environmental factors. METHOD Finnish hospital diagnoses of schizophrenic/paranoid psychosis in a nationwide sample of adopting-away women are compared with DSM-III-R research diagnoses for these mothers. DSM-III-R diagnoses of their(More)
Quantitative photoacoustic tomography (QPAT) offers the possibility of high-resolution molecular imaging by quantifying molecular concentrations in biological tissue. QPAT comprises two inverse problems: (1) the construction of a photoacoustic image from surface measurements of photoacoustic wave pulses over time, and (2) the determination of the optical(More)
BACKGROUND Diverse forms of thought disorder, as measured by the Thought Disorder Index (TDI), are found in many conditions other than schizophrenia. Certain thought disorder categories are primarily manifest during psychotic schizophrenic episodes. The present study examined whether forms of thought disorder qualify as trait indicators of vulnerability to(More)
The aim of the study was to evaluate whether thought disorders are stable, trait-like features specific to subjects who have a genetic liability to schizophrenia or a psychiatric disorder. The thought disorders of adoptees genetically at high risk (HR) or low risk (LR) for schizophrenia from the Finnish adoptive family study of schizophrenia were evaluated(More)
Keywords: Optical tomography Radiative transfer equation Inverse problems Finite element method Gauss–Newton method a b s t r a c t The radiative transfer equation can be utilized in optical tomography in situations in which the more commonly applied diffusion approximation is not valid. In this paper, an image reconstruction method based on a frequency(More)
Real-time imaging of human brain has become an important technique within neuroimaging. In this study, a fast and efficient sensitivity map generation based on Finite Element Models (FEM) is developed which utilises a reduced sensitivitys matrix taking advantage of sparsity and parallelisation processes. Time and memory efficiency of these processes are(More)
Communication deviance (CD), forms of communication that are not bizarrely thought disordered but are hard to follow and that make difficult the consensual sharing of attention and meaning, has been hypothesized as a nonspecific contributor of rearing parents to psychopathology of offspring, including schizophrenia. This hypothesis, or an alternative of(More)
Quantitative photoacoustic tomography (QPAT) aims to recover the optical absorption and scattering properties of a tissue region from a given photoacoustic image. Since a photoacoustic image is proportional to the product of the absorption coefficient and the absorption-dependent light fluence, recovering these properties is a nonlinear, ill-posed inverse(More)
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