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  • Hugh P. Morgan, Francis J O'Reilly, +4 authors Malcolm D. Walkinshaw
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences
  • 2013 (First Publication: 25 March 2013)
  • We show that the M2 isoform of pyruvate kinase (M2PYK) exists in equilibrium between monomers and tetramers regulated by allosteric binding of naturally occurring small-molecule metabolites.Expand
  • David Dornan, Harumi Shimizu, Lindsay R. Burch, Amanda J. Smith, Ted R. Hupp
  • Medicine, Biology
  • Molecular and Cellular Biology
  • 2003 (First Publication: 1 December 2003)
  • ABSTRACT The transcription coactivator p300 cannot acetylate native p53 tetramers, thus revealing intrinsic conformational constraints on p300-catalyzed acetylation. Consensus site DNA is anExpand