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Current multi-scale computational models of ventricular electromechanics describe the full process of cardiac contraction on both the micro- and macro- scales including: the depolarization of cardiac cells, the release of calcium from intracellular stores, tension generation by cardiac myofilaments, and mechanical contraction of the whole heart. Such models(More)
STUDY OBJECTIVE The purposes of this study were to estimate and compare the incidence of vaginal cuff dehiscence after different modes of hysterectomies (abdominal, vaginal, laparoscopic-assisted vaginal and laparoscopic) and to review the characteristics of hysterectomies complicated by vaginal dehiscences. DESIGN Observational case series (Canadian Task(More)
OBJECTIVE To provide insight into the impact of radical prostatectomy (RP) on prostate cancer-specific mortality (PCSM) in a primarily prostate-specific antigen screen-detected cohort of men with localized prostate cancer (PCa). METHODS Between 2000 and 2013, 1864 men consented to participate in a prospective longitudinal outcomes study after RP for(More)
OBJECTIVE To compare the size of the genital hiatus in women wearing a pessary for pelvic organ prolapse after consistent pessary use, describe characteristics of patients who continue use, and assess change in pelvic floor symptoms. METHODS This was an observational cohort study of 90 women seeking nonsurgical management of symptomatic prolapse. Our(More)
Focal therapy of prostate cancer is an evolving treatment strategy that destroys a predefined region of the prostate gland that harbors clinically significant disease. Although long-term oncologic control has yet to be demonstrated, focal therapy is associated with a marked decrease in treatment-related morbidity. Focal laser ablation is an emerging(More)
PURPOSE Mechanisms of immune dysregulation associated with advanced tumors are relatively well understood. Much less is known about the role of immune effectors against cancer precursor lesions. Endometrioid and clear-cell ovarian tumors partly derive from endometriosis, a commonly diagnosed chronic inflammatory disease. We performed here a comprehensive(More)
PURPOSE Endometriosis, a largely benign, chronic inflammatory disease, is an independent risk factor for endometrioid and clear cell epithelial ovarian tumors. We aimed to identify plasma miRNAs that can be used to differentiate patients with endometriosis and ovarian cancer from healthy individuals. EXPERIMENTAL DESIGN We conducted a two-stage(More)
STUDY OBJECTIVE To compare the effect of mechanical bowel preparation using oral sodium phosphate (NaP) solution vs single NaP enema on the quality of the surgical field in patients undergoing advanced gynecologic laparoscopic procedures. DESIGN Single-blind randomized controlled trial (Canadian Task Force classification I). SETTING Academic teaching(More)
The incidence of abnormal placentation is increasing as a result of the rise in the cesarean delivery rate. Management of placenta percreta involving the urinary bladder often requires extensive surgery including bladder resection. A 27-year-old woman with placenta previa percreta that invaded the urinary bladder underwent delayed total laparoscopic(More)
We introduce and compare three different modalities to study seismocardiogram (SCG) and its correlation with cardiac events. We used an accelerometer attached to the subject sternum to get a reference measure. Cardiac events were then approximately identified using echocardiography. As an alternative approximation, we used consecutive Cine-MRI images of the(More)