Ted Conway

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The objective of the present research is to develop a standard hexahedral Finite Element (FE) model of the human femur accounting for the material characteristics of cortical bone, cancellous bone and bone marrow. The anatomical data were acquired from the Visible Human Project. A detailed outline of the steps necessary in developing hexahedral FE meshes(More)
Benzenesulfohydroxamic acid (Piloty's acid) was functionalized on the hydroxyl group with the N,N-diethylcarbamoyl group, and the hydroxylamine nitrogen was substituted with acetyl (1a), pivaloyl (1b), benzoyl (1c), and ethoxycarbonyl (1d) groups. Only compound 1d inhibited yeast aldehyde dehydrogenase (AlDH) in vitro (IC(50) 169 microM). When administered(More)
Traumatic Brain injury (TBI) is a leading cause of death and disability among children and young adults in United States, with an estimated 1.5 million Americans sustaining TBI (CDC, 1999). The cranio-cerebral complex is the most severely affected region during an automobile accident. This is because of transfer of high amount of kinetic energy to the upper(More)
The prototypic aromatic C-nitroso compound, nitrosobenzene (NB), was shown previously to mimic the effect of nitroxyl (HN=O), the putative active metabolite of cyanamide, in inhibiting aldehyde dehydrogenase (AlDH). To minimize the toxicity of NB in vivo, pro-prodrug forms of NB, which were designed to be bioactivated either by an esterase intrinsic to AlDH(More)
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