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BACKGROUND The objective of this study was to determine the clinical characteristics, treatment response, and frequency of p53 overexpression in Ashkenazi Jewish women with hereditary ovarian carcinoma. METHODS Seventy-one Jewish women with epithelial ovarian carcinoma (EOC) were tested for the three BRCA founder mutations using single-strand conformation(More)
Bromides were formerly used for their sedative and anti-convulsant properties. The neuropsychiatric features of bromide intoxication have been recognized for many years (Barbour, Pilkington and Sargent, 1936). Carney (1971) described 5 cases of bromism and advocated stricter control on bromide preparations. Part III of the Medicine Act (1978) made potassium(More)
OBJECTIVE To determine if the quantity of lymph-vascular space invasion influences the risk of pelvic nodal metastases in women with early-stage cervical squamous carcinoma. METHODS Between 1991 and 1997, 105 women with stages IA2, Ib, and IIa squamous carcinoma of the cervix underwent radical hysterectomy and pelvic lymphadenectomy. The histopathology(More)
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