Taylor J. Schoberle

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Mycobacterium leprae causes leprosy. M leprae strains collected worldwide have been genetically clonal, which poorly explains the varying severity and clinical features of the disease. We discovered a new Mycobacterium species from 2 patients who died of diffuse lepromatous leprosy (DLL). The Mycobacterium was purified from heavily infected, freshly frozen(More)
Fungal species are continuously being studied to not only understand disease in humans and plants but also to identify novel antibiotics and other metabolites of industrial importance. Genetic manipulations, such as gene deletion, gene complementation, and gene over-expression, are common techniques to investigate fungal gene functions. Although advances in(More)
Secondary metabolites are produced by numerous organisms and can either be beneficial, benign, or harmful to humans. Genes involved in the synthesis and transport of these secondary metabolites are frequently found in gene clusters, which are often coordinately regulated, being almost exclusively dependent on transcription factors that are located within(More)
Aspergillus fumigatus is an opportunistic pathogenic fungus that primarily infects neutropenic animal hosts. This fungus is found throughout the world, can utilize a wide range of substrates for carbon and nitrogen sources, and is capable of growing at elevated temperatures. The ability to grow at high temperatures and utilize a range of nutrient substrates(More)
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