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Prompt Immune Tolerance Induction at Inhibitor Diagnosis Regardless of Titer May Increase Overall Success in Hemophilia A With Inhibitors: Experience of Two US Centers
Introduction Immune tolerance induction (ITI) for patients (pts) with hemophilia A with inhibitors is the only modality known to effectively eradicate inhibitors with an overall reported success ofExpand
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Long-Term Orthopedic Effects Of Delaying Prophylaxis In Severe Hemophilia A Until Age 6 Years: Results Of The Joint Outcome Study Continuation (JOSc)
The Joint Outcome Study (JOS) was a randomized controlled clinical trial in boys with severe factor VIII deficiency comparing prophylaxis consisting of 25 IU/kg factor VIII every other day begunExpand
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Natural History Of Hemophilic Joint Disease Using Sensitive Imaging With Magnetic Resonance Imaging (MRI)
![Graphic][1] Introduction Arthropathy, the most costly chronic complication of severe hemophilia A (HemA) can be prevented by routine replacement of factor VIII (FVIII) when initiated prior toExpand
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Breakthrough Bleeding in Hemophilia a Patients on Prophylaxis
Background: Patients with severe hemophilia A (factor VIII (FVIII) Methods: To better understand breakthrough bleeding, we evaluated the effect of hemophilia severity, prophylaxis adherence, andExpand
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