Tayebeh Farhadi

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Klebsiella pneumoniae is a hospital-acquired pathogen that leads to various infections. There is a great interest in developing an efficient Klebsiella vaccine and epitope-based vaccines may provide a hopeful choice. Outer membrane proteins (Omps) of gram-negative bacteria play an essential role in bacterial pathogenicity; therefore, they are ideal(More)
Vibrio cholera, a gram-negative bacterium, has been categorised into clinical and environmental species. Phylogenetic studies have been performed to investigate the relationships of the V. cholerae populations in worldwide. In this study, phylogenetic relationship between V. cholerae isolates from Iran and other regions of the world was determined, based on(More)
Infectious diseases are an important cause of fatality worldwide and administration of vaccines could provide long-lasting protection against responsible infection. Incorporating of adjuvants to vaccine formulations can enhance the effectiveness of antigens. This study proposes an in silico approach for designing of some flagellin derivatives as adjuvant(More)
The Gram-negative bacterium Klebsiella pneumoniae, responsible for a wide variety of nosocomial infections in immuno-deficient patients, involves the respiratory, urinary and gastrointestinal tract infections and septicemia. Extended spectrum β-lactamases (ESBL) belong to β-lactamases capable of conferring antibiotic resistance in Gram-negative bacteria.(More)
Chlamydia trachomatis (Ct) is an intracellular pathogen that causes ocular and genital tract infections. Vaccines have an important role in management of Ct-caused diseases. Major outer membrane protein (MOMP) is the most abundant and one of the most studied proteins for utilizing as a Ct vaccine candidate. In this study, there was an attempt to take(More)
Drug-induced pregnane X receptor (PXR) activation may be unavoidable with some treatments. Besides, drug-induced PXR activation may lead to drug interactions with a number of treatments. Human PXR antagonists represent a means to counteract such interactions. Indeed, the ideal small molecule would have good drug-like properties, but be devoid of nonspecific(More)
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