Tatyana P. Novgorodtseva

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BACKGROUND Disturbances of the fatty acids composition in plasma and red blood cells and eicosanoid synthesis play an important role in the metabolic syndrome (MS) formation. METHODS The observation group included 61 people with metabolic syndrome (30 patients with MS and normal levels of insulin, 31 people with MS and insulin resistance--IR). The(More)
BACKGROUND Modification of fatty acids (FA) composition in erythrocytes lipids as an early indicator of the development of arterial hypertension (AH) and lipid disorders. METHODS We included 34 patients with arterial hypertension and 11 healthy individuals. Each patient was examined the lipid composition of serum. From erythrocytes by gas chromatography(More)
Early preclinical diagnosis of COPD is urgent. We proposed that fatty acid composition of red blood cells may serve as a prognostic test for the complications in the chronic respiratory diseases. Fatty acid composition of the erythrocyte membranes in patients with chronic respiratory diseases (chronic bronchitis, CB, and stable chronic obstructive pulmonary(More)
Background. Comorbidity of chronic obstructive pulmonary disease (COPD) and asthma (asthma COPD overlap syndrome, ACOS) is a significant problem in pulmonary practice, whose pathogenetic issues are not clarified yet. Objective. To study the features of the regulation of immune response in patients with comorbid COPD and asthma. Methods. We assessed the(More)
Contradictory data on consequences of prolonged high-fat diet requires a detailed study of the influence of nutritional high-fat load mechanisms on the peculiarity of lipid metabolism in blood and liver. The present study was undertaken to investigate the fatty acid composition of polar and neutral lipids of the blood plasma, erythrocytes and liver in(More)
The effects of high-fat diet on the thiol disulfide homeostasis of rats were evaluated by activities of glutathione redox system functioning in the blood and liver. A short-term (30 days) high-fat diet inhibited activities of glutathione-dependent enzymes. High-fat loading for 90 days promoted the development of a compensatory response of the glutathione(More)
We studied heme oxygenase-1 expression in rat liver during the development of nonalcoholic steatohepatitis simulated by feeding high-fat ration for 30, 90, and 180 days. Increased number of hepatocytes synthesizing heme oxygenase-1 was demonstrated at all stages of pathology development. Herewith, the intensity of enzyme expression by individual cells was(More)
The new model of nonalcoholic steatohepatitis in rats is based on alimentary effects of hypercaloric diet including much cholesterol and beef fat. This model reproduces structural and functional disorders in the liver, including hepatocyte fatty degeneration, parenchymatous necrosis and fi brosis paralleled by dyslipidemia and is intended for studies of the(More)
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