Tatyana A Savina

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Experiments on Krushinskii-Molodkina rats with hereditary predisposition to audiogenic seizures showed that chronic consumption of aqueous solution of melatonin (50 mg/liter) had no effect on the pattern of seizures induced by 20-fold acoustic stimulation. Sodium valproate (50 mg/liter) insignificantly decreased the seizure response. Combined treatment with(More)
Analysis of extracellular recordings of evoked excitatory postsynaptic potentials and population spikes from rat hippocampal slices has previously revealed that repeated, brief exposures to high extracellular K(+) or to episodes of hypoxia induce a sustained (more than 3 h) hyperexcitability of CA1 pyramidal neurons accompanied with epileptiform activity(More)
Extrapulmonary tuberculosis mainly afflicted females over 60 years of age; males aged 20-29 years suffered from this disease concurrent with HIV infection. The major site of extrapulmonary tuberculosis was the urogenital tract; however, the incidence of tuberculosis of the nervous system considerably increased. At the same time abdominal tuberculosis was(More)
Using a Western blot method it was been shown that a aontent of beta-CaMKII subunit was decreased on 40 % in hippocampus of Krushinskii-Molodkina rats (rats, genetically prone to audiogenic seizures) in comparison with normal Wistar rats. Additionally, we have investigate the temporal modifications of alpha/beta-CaMKII subunits in dependent from number(More)
The goal of this study is to evaluate the effects of anti-inflammatory cytokine interleukin-10 (IL-10) on the repeated brief hypoxia-induced changes in expressions of AMPA receptor subunit GluA1 and α- and β-subunit of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII). The hypoxia-induced changes in the rat hippocampal slice CA1 neuronal activities(More)
Ca2+-calmodulin-dependent protein kinase II (CaMKII) and protein phosphatase 2B (calcineurin) play critical roles in the formation of nerve cell responses to incoming Ca2+ signals. The studies report here addressed how single seizures might affect the functioning of these enzymes. Sounds (80 dB, 12–15 kHz) induced single convulsions in male(More)
The paper presents the results of follow-up of 894 patients in 1983 - 1993. The increasing topicality for physiology and the potentialities of making the diagnosis of the disease better are defined, based on the data on the pathogenesis and pathomorphism of tuberculous lymphadenitis and on the results of testing new diagnostic techniques, including(More)
Rats Krushinsky-Molodkina inbred strain (KM) genetically prone to audiogenic seizures were injected with pineal hormone melatonin (50 mg/kg, s.c.) within the period 7th to the 14th posnatal days (PND). The remote effects of this injection adult KM rats consisted in a decrease in the latency and increase in severity of myoclonic seizures produced by(More)