Tatyana A. Kuznetsova

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1,8-Dihydroxy-6-methoxy-3-methyl-9,10-anthracenedione (physcion, 1), 3,4-dihydro-3,6,9-trihydroxy-8-methoxy-3-methyl-1(2H)-anthraceneone (asperflavin, 2), and 2,5-dihydroxy-3-(3-methyl-2-butenyl)-6-[(1E)-1-heptenyl]-benzaldehyde (tetrahydroauroglaucin, 3) were shown to be the main pigments of the marine isolate of the fungus Eurotium repens. In addition to(More)
BacteriaVibro sp. isolated from the spongeDysidea sp. were shown to biosynthesize brominated diphenyl ethers. We identified one of the bacterial brominated metabolites using gas liquid chromatography and mass spectrometry to compare this product with standard 3,5-dibromo-2-(3′,5′-dibromo-2′-methoxyphenoxy)phenol. The latter has been isolated from ethanol(More)
Antitumor and antimetastatic activities of fucoidan, a sulfated polysaccharide isolated from Fucus evanescens (brown alga in Okhotsk sea), was studied in C57Bl/6 mice with transplanted Lewis lung adenocarcinoma. Fucoidan after single and repeated administration in a dose of 10 mg/kg produced moderate antitumor and antimetastatic effects and potentiated the(More)
A marine bacterium (KMM 1364), identified as Bacillus pumilus, was isolated from the surface of ascidian Halocynthia aurantium. Structural analysis revealed that the strain KMM 1364 produced a mixture of lipopeptide surfactin analogs with major components with molecular masses of 1035, 1049, 1063, and 1077. The variation in molecular weight represents(More)
Based on our own and current literature data, we analyzed the prebiotic properties of polysaccharides and extracts of seaweeds. The role of prebiotics, particularly polysaccharides, in the normalization of intestinal microflora is discussed; consideration is also given to the possibility of seaweed polysaccharide fermentation by colonic microflora and(More)
This study used a pharmacological approach to evaluate the consequences of the metabolic perturbations of neurotransmitters on brain development. Pregnant rats received p-chlorophenylalanine (pCPA), an inhibitor of serotonin (5-hydroxytryptamine, 5-HT) synthesis, or saline (control) from the 11th day of gestation once or daily up to the 15th, 17th and 20th(More)
We previously isolated from the marine isolate of the fungus Aspergillus fumigatus KMM 4631 the five diketopiperazine antibiotics cyclotryprostatins A and B, fumitremorgin C, 12, 13-dihydrofumitremorgin C, and verruculogen [1]. Further research on metabolites of this strain afforded 1-5. Cultivation was performed under the previously described conditions(More)
Four yellow-pigmented, gram-negative, chemoorganotrophic aerobic bacteria were isolated from starfish Stellaster equestris (strains 022-2-10T, 022-2-9, and 022-2-12) and soft coral (unidentified species) (strain 022-4-7) collected in the South China Sea. 16S rRNA gene sequence-based analyses of the new organisms revealed that Erythrobacter spp. were the(More)
A competitive ELISA using the intact toxin as a coating antigen for detecting palytoxin was developed. This immunoassay allows palytoxin (PTX) to be determined in the range of 6–250 ng/ml. In sensitivity, this determination is comparable with RIA but is three times inferior to ELISA using monoclonal antibodies. Inhibition experiments using some toxins of(More)
Fucoidans isolated from Fucus evanescens and Laminaria cichorioides kelp can inhibit thrombin and factor Xa of the blood coagulation system. In rats, intravenous injection of fucoidans dose-dependently increased anticoagulant activity of the plasma. Fucoidans can form complexes with protamine sulfate. The observed quantitative differences in the action of(More)