Tatsuya Mimura

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PURPOSE To investigate whether interleukin-6 (IL-6) or vascular endothelial growth factor (VEGF) is related to diabetic macular edema (DME) in subjects without posterior vitreous detachment (PVD). DESIGN Retrospective case-control study. PARTICIPANTS Twenty-six subjects who had DME without PVD and 12 subjects who had nondiabetic ocular disease (the(More)
Cytokine levels are elevated in the ocular fluid of diabetic patients. It is unclear whether aqueous humor levels of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) are related to the vitreous fluid levels of these substances and to the progression of diabetic retinopathy. Aqueous humor and vitreous fluid samples were obtained during(More)
PURPOSE To investigate the relationship between diabetic macular edema and the levels of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) in aqueous humor and plasma. DESIGN Comparative cross-sectional study. METHODS Fifty-four eyes from 54 diabetic patients were used. The concentrations of VEGF and IL-6 in undiluted aqueous specimens(More)
We assessed the major factors regulating adiponectin levels and the influence of exercise training on adiponectin levels in young obese men (19.2±1.1 yrs, BMI: 31.1±4.2, %fat: 27.2±3.9%). Subjects were separated into three groups (aerobic exercise group [AE: n=7], aerobic and resistance exercise group [AE+RE: n=7], control group [n=7]). AE underwent an(More)
PURPOSE Human corneal endothelial cells (HCECs) are considered to be nonreplicative in vivo; however, isolated HCECs can be cultured and grown successfully, indicating that they retain proliferative capacity. This capacity to replicate tends to decrease with donor age. Cyclin-dependent kinase inhibitors (CKIs) are important negative regulators of the cell(More)
PURPOSE To evaluate the association between vitreous inflammatory factors and the severity of diabetic macular edema (DME). DESIGN Retrospective case-control study. PARTICIPANTS Fifty-three patients with DME, 15 patients with nondiabetic ocular disease, and 8 diabetic patients without retinopathy. METHODS Vitreous fluid samples were obtained during(More)
OBJECTIVE To investigate whether interleukin (IL)-6 or vascular endothelial growth factor (VEGF) influences macular edema in patients with central retinal vein occlusion (CRVO). DESIGN Retrospective case-control study. PARTICIPANTS Twenty-seven patients who had macular edema with CRVO and 16 patients with nonischemic ocular diseases (control group). (More)
PURPOSE To investigate whether vitreous levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) are related to diabetic macular edema (DME). DESIGN Retrospective case-control study. PARTICIPANTS Thirty-six patients with DME, 6 diabetic patients without retinopathy, and 13 patients with nondiabetic ocular disease.(More)
PURPOSE To isolate precursors of human corneal endothelial cells (HCECs) in vitro. METHODS HCECs were subjected to a sphere-forming assay in which spheres floated in serum-free medium containing growth factors. To promote differentiation, the isolated sphere colonies were plated in dishes coated with poly-L-lysine (PLL)/laminin or fetal bovine endothelium(More)
PURPOSE To isolate fibroblast precursors from rabbit corneal stroma using a sphere-forming assay, to engineer corneal stroma with the precursors and gelatin, and to establish the therapeutic application of precursors in a rabbit corneal stroma. METHODS In the in vitro study, a sphere-forming assay was performed to produce precursors from rabbit corneal(More)