Tatsuya Ishizuka

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The genetically obese Koletsky rat (SHROB, fa k) has a novel point mutation of the leptin receptor at amino acid ϩ763, resulting in a premature stop codon in the leptin receptor extracellular domain. This implies that all leptin receptor isoforms should be absent in this model. We examined the phenotypic consequences of this mutation on leptin and leptin(More)
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