Tatsuya Fujisaki

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For cancer metastasis, tumor cells present in the circulation must first adhere to the endothelium. Integrins lymphocyte function-associated antigen (LFA) 1 and very late antigen 4 play a central role in leukocyte adhesion to the endothelium and subsequent migration into tissues. The majority of tumor cells derived from solid cancers including colorectal(More)
OBJECTIVE The mechanism of neutrophil adhesion to the endothelium during the earliest stages of acute inflammation, especially before the induction of adhesion molecules on endothelial cells, remains unknown. We studied the possible involvement of platelets in this process. METHODS Neutrophils were added to human umbilical vein-derived endothelial cells(More)
OBJECTIVE Endoscopic ultrasonographic (EUS) changes in gastroesophageal reflux disease (GERD) after treatment with proton pump inhibitor have been poorly evaluated. We conducted a randomized, double-blind 12-wk clinical trial to compare the EUS effects of lansoprazole to histamine H2-receptor antagonist therapy in GERD. METHODS Seventeen patients with(More)
Recruitment of neutrophils into tissue occurs in several pathologic processes such as inflammation, atherosclerosis, thrombosis, and ischemia. In inflammation, the adherence of neutrophils to the endothelium depends on neutrophil integrins. Integrin-mediated adhesion is tightly regulated, ie, integrins do not function if neutrophils are not triggered by(More)
PURPOSE To aid in the selection of incident X-ray energy for stereotactic irradiation (STI) of lung tumor, dose distribution was investigated in a model of a thorax embedded with a tumor. METHODS AND MATERIALS The dose distribution in a thorax model was calculated using the EGS4 Monte Carlo simulation; it was also measured with dosimetric film of a(More)
We describe the displacement of the beam-axis from the planning isocenter in clinical situations during three-dimensional conformal radiosurgery using an Acculeaf bi-directional micro-multileaf collimator. The displacements were recorded for 64 ports using a video imaging system and a stereotactic arc. The mean displacement was 0.41+/-0.25 mm.
To experimentally and theoretically evaluate dose distribution during lung stereotactic radiotherapy, we investigated the relative electron densities in lung and tumor tissues using X-ray computed tomography images obtained from 30 patients in three breathing states: free breathing, inspiration breath-hold, and expiration breath-hold. We also calculated(More)
A method for the analysis of fatigue parameters has been rarely researched in VDT operation. Up to now, fatigue was evaluated by changing of biological information. If signals regarding fatigue are detected, fatigue can be measured. This study proposes an experiment and analysis method to extract parameters related to fatigue from the biological information(More)