Tatsuya Fujisaki

Learn More
Recruitment of neutrophils into tissue occurs in several pathologic processes such as inflammation, atherosclerosis, thrombosis, and ischemia. In inflammation, the adherence of neutrophils to the endothelium depends on neutrophil integrins. Integrin-mediated adhesion is tightly regulated, ie, integrins do not function if neutrophils are not triggered by(More)
To investigate the demographic details and patterns of injuries related to horse handling, we reviewed 637 horse-related injuries in 581 stable- or stud-workers in a representative area of thoroughbred stabling in Japan. We found that (1) injuries occurred most frequently in a group of a relatively young workers, with a seasonal variation; (2) the principal(More)
OBJECTIVE Endoscopic ultrasonographic (EUS) changes in gastroesophageal reflux disease (GERD) after treatment with proton pump inhibitor have been poorly evaluated. We conducted a randomized, double-blind 12-wk clinical trial to compare the EUS effects of lansoprazole to histamine H2-receptor antagonist therapy in GERD. METHODS Seventeen patients with(More)
OBJECTIVE The mechanism of neutrophil adhesion to the endothelium during the earliest stages of acute inflammation, especially before the induction of adhesion molecules on endothelial cells, remains unknown. We studied the possible involvement of platelets in this process. METHODS Neutrophils were added to human umbilical vein-derived endothelial cells(More)
For cancer metastasis, tumor cells present in the circulation must first adhere to the endothelium. Integrins lymphocyte function-associated antigen (LFA) 1 and very late antigen 4 play a central role in leukocyte adhesion to the endothelium and subsequent migration into tissues. The majority of tumor cells derived from solid cancers including colorectal(More)
PURPOSE To aid in the selection of incident X-ray energy for stereotactic irradiation (STI) of lung tumor, dose distribution was investigated in a model of a thorax embedded with a tumor. METHODS AND MATERIALS The dose distribution in a thorax model was calculated using the EGS4 Monte Carlo simulation; it was also measured with dosimetric film of a(More)
The contribution of Cerenkov radiation in high-energy film dosimetry was investigated using commercially available water-substitute phantoms. Doses were evaluated using six phantoms: RMI-451, Mix-DP, WE-211, WE-Black, PMMA and PMMA-Black. The contribution of Cerenkov radiation was determined from the shielded and unshielded evaluation doses when a bare film(More)
To experimentally and theoretically evaluate dose distribution during lung stereotactic radiotherapy, we investigated the relative electron densities in lung and tumor tissues using X-ray computed tomography images obtained from 30 patients in three breathing states: free breathing, inspiration breath-hold, and expiration breath-hold. We also calculated(More)